Certain major risk factors of atherosclerosis are recognized and methods for their early detection and regulation should result in a decreased incidence of deaths from atherosclerotic complications.
Our studies, while considering the multifaceted nature of the disease process, have concentrated on the relation of lipoproteins to atherosclerosis, and factors regulating serum lipid and lipoprotein levels including genetic, physiologic, environmental, and immunologic mechanisms.
Animal studies have included comparative physiologic investigations to try to explain why one species such as dogs are relatively resistant, while another, man, spontaneously develops atherosclerosis.
Studies on human beings have evaluated serum lipoproteins of a large population segment of healthy subjects of the Cleveland area, of groups of distinctive ethnic and genetic background from central Africa; natives of St. Kitts, British West Indies; Indians of Peru and Arizona; and Alaskan Eskimos. Detailed investigations were made of a selected group of subjects studied individually over relatively long periods.
The concept as originally elaborated so clearly by Page1 in his Connor lecture that atherosclerosis is a disease resulting from interaction of many factors still probably most accurately describes the etiology of atherosclerosis. This was elaborated into the Atherosclerotic Mosaic Theory. Studies described below, carried out at the Cleveland Clinic for the past quarter century provide additional blocks to support the “multifaceted” concept as do works from many centers around the world.Experimental animals
Lipoprotein patterns of sera of different animal species and strains were studied to determine whether any characteristics were common to those which develop spontaneous atherosclerosis or . . .