Treatment of Benign Prostatic Hypertrophy by a Nonoperative Method

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At the June 1935 meeting of the American Medical Association at Atlantic City, I gave a clinical report on the treatment of benign prostatic hypertrophy by nonoperative methods before the Section on Urology.

In 1928, we began an experimental research to see if we could find a more tenable explanation of the etiology of benign prostatic hypertrophy. As a result of this experimental work, we believed that an endocrine imbalance was the most likely explanation, and D. Roy McCullagh has discussed our experimental findings in the paper presented in this issue.

In the first preliminary report at Atlantic City, we presented our results in the treatment of 40 cases of benign prostatic hypertrophy and since then, we have added 36 more, so that we now have 76 cases in which we have sufficient records to make the additional report. In spite of persistent efforts, a suitable method of assay has not been developed. For this reason, it has been impossible to determine what chemical fraction of the glands contains the hormone “inhibin,” and equally impossible to know whether or not all our preparations were of the same strength and what dose of hormone each patient received. Each patient received the equivalent of 60 grams of fresh beef testicular material daily. The material was completely desiccated in vacuo at 60 degrees Centigrade and was administered in powder form in gelatin capsules.

The type of case in which we have used this medication has varied somewhat, but we have felt that it. . .



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