Calcification in the liver, an unusual feature of ductal cell hepatic carcinoma
Phillip M. Hall, M.D.
Department of Internal Medicine
Eugene I. Winkelman, M.D.
Department of Gastroenterology
William A. Hawk, M.D.
Department of Pathology
Robert E. Hermann, M.D.
Department of General Surgery
CALCIFICATIONS in the liver occur rarely. Roentgenographically, such deposits of calcium may appear as discrete, structured elements, or may be distributed diffusely and irregularly. Histologically the calcium may be deposited amorphously, as dystrophic calcification, or may be organized into new bone.
In the case reported in this paper, the patient had intrahepatic calcification as the first manifestation of a ductal cell carcinoma of the liver. In addition to malignant cells, the neoplasm contained areas of dense fibrosis, amorphous calcium deposits, and new bone. Since carcinoma of the liver as a cause of intrahepatic calcification is rare, the varied etiopathogenesis of the latter is discussed and a review of the pertinent literature is presented.
Report of a case
A 32-year-old Caucasian man was first examined at the Cleveland Clinic in March, 1965, because of weakness, and roentgenographic evidence of calcification of the liver. Four years previously, the patient was first noted to have asymptomatic enlargement of the liver. There was evidence of calcifications in the right upper part of the abdomen at the time of barium enema study in 1964 and again in January 1965. Varicella developed in February 1965, at which time the patient was noted to have an increase in alkaline phosphate, serum glutamic oxaloacetic transaminase (SGOT), and sulfobromophthalein sodium retention, but the serum bilirubin content was normal. On April 19, 1965, he was admitted to the Cleveland Clinic Hospital for further evaluation.
On physical examination the patient appeared to be well developed and well nourished. The temperature was . . .