Bronchial Adenoma

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BRONCHIAL adenoma diagnosed clinically and bronchoscopically was reported by Kramer1 in 1930; two years later Wessler and Rabin2 designated bronchial adenoma as a definite clinicopathologic entity. The same type of tumor had been described by Ephraim3 in 1911 as “sarcoma of alveolar pattern,” by Kreglinger4 in 1913 as “cylindrical cell sarcoma,” and by Geipel5 in 1931 as “benign basal cell cancer.”

In 1937 Hamperl6 published a meticulous histologic study of the disorder and suggested that the adenoma was derived from mucous glands of the bronchi. He described nine cases; in two the histologic pattern was similar to the cylindromatous pattern of certain salivary gland tumors so he referred to the neoplasms as “cylindromas.” Five of the remaining seven cases Hamperl called “carcinoid variant” on the basis of the resemblance of the histologic pattern to that of carcinoid tumors of the appendix reported previously. In the remaining two neoplasms, he found a special type of epithelial cell that he called an “oncocyte,” a cell that he believed was present in other parts of the body besides the salivary glands, such as thyroid, parathyroid, pancreas, liver, and pituitary gland; he was unable to determine whether oncocytes have a function.

Concerning the possible etiology of bronchial adenoma, Stout7 in 1943 reported finding all of the features of the oncocytes previously described by Hamperl.6 Stout stressed the great difference between the oncocytes and other cells in the bronchial mucous membrane, and concluded that the oncocyte warrants serious consideration as the probable cell of origin, . . .



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