The Comparative Values of Retrograde and Intravenous Urography


The historical background for the visualization of the urinary tract by means of the injection of an opaque medium is well known from the time of von Lichtenberg’s1 pyelography to the present era of intravenous urography. However, one incident of experimentation in the evolution of this diagnostic procedure should be borne in mind in every discussion of the subject, and that is the work of Osborne, Sutherland, Scholl, and Rowntree,2 who in 1923 performed intravenous pyelography using sodium iodide. Owing to the imperfections of their preparations, however, they were unable to make the procedure practical.

The preparations which are in use at the present time are stable, organic iodide compounds. The first of these was selectan neutral which was introduced by Binz and Rath3 in 1925 for the purpose of combating coccus infections. By the intravenous use of this agent they were able to visualize the urinary tract and this led to further efforts to obtain a product of less toxicity which would be capable of greater concentration. Roseno4 came forward with pyelognos, which however, was not satisfactory, and it was left for Swick,5 of New York, to perfect a preparation which he called uroselectan. This preparation proved to be of practical application and immediately intravenous pyelography became a prominent roentgenologic procedure. Since then the preparations of skiodan and abrodil have been brought into use. These contain 52 per cent of iodine as compared with uroselectan which contains only 40 per cent. The latest preparation, neo-iopax, is in solution and. . .



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