News

Advanced Age Shortens LVAS Survival Time


 

PHILADELPHIA — Older patients are much less likely to survive their first year on a ventricular assist device than are younger patients, according to a review of 1,365 patients who have received such devices.

But many patients who are at least 60 years old can often benefit from a left ventricular assist device, Peer M. Portner, Ph.D., said at the annual meeting of the International Society for Heart and Lung Transplantation.

“Age is likely a surrogate marker for comorbid conditions at the time of the implant. Left ventricular assist systems [LVAS] can produce a strong survival benefit, even in the oldest patients. This underscores the importance of patient selection for destination therapy,” said Dr. Portner, of the department of cardiothoracic surgery at Stanford University in Palo Alto, Calif., and developer of the Novacor LVAS.

“We have an idea of which patients will do better, but it's been hard to collect the data that could help” identify the patients who will have the best outcomes after receiving an LVAS, he said.

The analysis reported by Dr. Portner came from a registry of patients who received the Novacor LVAS in 1984–2003. During that period, 1,461 patients received the device at 98 centers worldwide. This analysis excluded 70 patients who received the device as destination therapy and 26 patients with inadequate follow-up data, which left 1,365 patients who received the device as a bridge to transplant. The average period of implantation prior to receiving a heart transplant was 144 days for the entire group, but today the average period during which the implant is in place is about 1 year.

Outcomes data were analyzed by the patients' age, and the database was divided into four groups that had similar numbers of patients: those aged 12–39 years (316 patients), aged 40–49 years (353), aged 50–59 years (451), and aged at least 60 years (245).

A logistic regression analysis showed that death during the first year with the device was directly linked to age. Patients in the oldest subgroup (at least 60) had a 2.4-fold increased risk of death compared with all other patients. In contrast, the youngest patients (younger than 40) had a 50% lower risk of death compared with the other patients. The two intermediate age groups had mortality risks between these two extremes.

Expressed another way, the survival rate at 1 year was 75% in patients younger than 40, 70% in those aged 40–49 years, 60% in patients aged 50–59 years, and 40% in those aged at least 60 years. Although mortality was high in older patients, the data also showed that a significant number of older patients could survive beyond 1 year on a LVAS.

“It's unfortunate that we're stuck in the United States with having a separate indication for destination therapy,” said Dr. Portner. “The decision on the ultimate outcome of a recipient of an assist device should depend on how they progress.”

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