Clinical Edge Journal Scan

Meta-analysis shows link between pretreatment prognostic nutritional index and survival in breast cancer


Key clinical point: Improved pretreatment values of the prognostic nutritional index (PNI) , an indicator of nutritional immune status, was linked to better long-term survival outcomes in patients with breast cancer (BC).

Major finding: Although low pretreatment PNI did not have any effect on 1-year overall survival (OS) outcomes (odds ratio [OR] 1.55; P = .353), it was significantly associated with worse 3-year (OR 2.34; P < .001), 5-year (OR 3.18; P < .001), 8-year (OR 2.74; P = .001), and 10-year (OR 2.58; P = .021) OS.

Study details: Findings are from a meta-analysis of eight studies including 2322 patients with BC.

Disclosures: This study was funded by the National Natural Science Foundation of China and other sources. The authors declared no conflicts of interest.

Source: Hu G et al. Low pretreatment prognostic nutritional index predicts poor survival in breast cancer patients: A meta-analysis. PLoS One. 2023;18(1):e0280669 (Jan 20). Doi: 10.1371/journal.pone.0280669

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