Breast conserving surgery plus radiotherapy superior to mastectomy in breast ductal carcinoma in situ with microinvasion

Key clinical point: Breast conserving surgery (BCS) plus radiotherapy (RT) demonstrated superior survival outcomes compared to mastectomy in patients with ductal carcinoma in situ with microinvasion (DCIS-MI).

Major finding: Overall survival (hazard ratio [HR] 0.676; P < .001) and breast cancer-specific survival (HR 0.565; P = .017) were significantly improved in the BCS+RT vs mastectomy group.

Study details: This study analyzed the data of 5432 patients with DCIS-MI from the Surveillance, Epidemiology, and End Results (SEER) database, of which 52.17% of patients had received BCS+RT.

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Disclosures: This study did not report a source of funding. The authors declared no conflicts of interest.

Source: Xia LY et al. Survival outcomes after breast-conserving surgery plus radiotherapy compared with mastectomy in breast ductal carcinoma in situ with microinvasion. Sci Rep. 2022;12:20132 (Nov 22). Doi: 10.1038/s41598-022-24630-7