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SOLO3: Olaparib outperforms chemo in heavily pretreated ovarian cancer
Response rate and progression-free survival were significantly better with olaparib than with nonplatinum chemotherapy.
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Tumor neoantigenicity metric improves prediction of response to immunotherapy
A new scoring system can predict response to immunotherapy in patients with melanoma, lung cancer, and kidney cancer.
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HBV: Surface antigen titer and ALT predict seroconversion
In patients with hepatitis B virus infection, surface antigen titer and alanine aminotransferase level may independently predict spontaneous...
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Shortened CAPOX regimen appears effective in stage II colorectal cancer
Five-year relapse-free survival rates were similar in patients who received 3 months or 6 months of CAPOX.
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CRC task force updates colonoscopy follow-up guidance
The new guidance was based on advancements in both research and technology since the last recommendations were published in 2012.
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U.S. Multi-Society Task Force publishes polypectomy guidance
The panelists' recommendations, which were based on both evidence and clinical experience, range from specific polyp removal techniques to...
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Breast cancer treatments veer from guidelines
Clinicians used genetic test results correctly when making surgical decisions, but decisions about radiotherapy and chemotherapy did not align...
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APOE genotype directly regulates alpha-synuclein accumulation
Two studies synergistically show how the APOE4 genotype is associated with cognitive decline in patients with Lewy body dementia.
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Large study probes colonoscopy surveillance intervals
Low-risk adenomas show same risk of colorectal cancer as no adenomas, so they may need no adjustment to surveillance interval.
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Mailed fecal testing may catch more cancer than endoscopic screening
At a population level, FIT screening had the highest advanced neoplasia detection rate, at 4.5%, compared with 2.3% and 2.2% for screening by...
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GALAD score predicts NASH-HCC more than a year in advance
The score, which combines sex, age, alpha-fetoprotein-L3, alpha-fetoprotein, and des-gamma-carboxyprothrombin is blood based and can replace...
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Circulating tumor cells at baseline predict recurrence in stage III melanoma
Patients with circulating tumor cells were three times more likely to have disease recurrence within 6 months.
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Esophageal length ratio predicts hiatal hernia recurrence
The manometric esophageal length-to-height ratio could offer a means of preoperatively identifying shortened esophagus.
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IBD: Inpatient opioids linked with outpatient use
Alternative analgesics should be considered for patients with inflammatory bowel disease.