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Extended AI therapy reduces breast cancer recurrence risk, ups fracture risk
SAN ANTONIO – A meta-analysis shows reduced breast cancer recurrence with extended AI therapy, but underscores need...
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Novel SSc classification scheme aims to improve risk stratification
CHICAGO – The scheme combines autoantibody specificity and extent of skin involvement.
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Combination immunotherapy ups survival in ILD patients with anti-MDA5–positive dermatomyositis
But cytomegalovirus reactivation and other opportunistic infections must be monitored.
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Dr. Ingrid A. Mayer on neoadjuvant endocrine therapy: The times are changing
SAN ANTONIO – More phase 2 neoadjuvant endocrine therapy breast cancer trials are needed to inform design of phase 3...
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Exercise during adjuvant breast cancer therapy improves CV outcomes
SAN ANTONIO – A tailored 12-month exercise program during adjuvant breast cancer treatment appears to protect...
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Extended anastrozole improves DFS, distant DFS
SAN ANTONIO – Extending treatment to 10 years significantly improved DFS and distant DFS in postmenopausal women...
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TNBC survival appears better when adjuvant chemotherapy is delivered within 30 days
SAN ANTONIO – The longer the delay in initiating adjuvant chemotherapy, the worse the survival in patients with...
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PD-L1 expression best predicts response to atezolizumab + nab-paclitaxel for mTNBC
SAN ANTONIO – IMpassion130 analyses show that PD-L1 expression on tumor-infiltrating immune cells is the best...
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2018: A banner year for hematology drug approvals
SAN DIEGO – There have been 32 new hematology drug approvals and the year isn’t over yet.
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Phase 3 study confirms biosimilarity of PF-05280586 with rituximab
PF-05280586 showed biosimilarity to rituximab at up to 26 weeks in a randomized phase 3 study of treatment-naive patients with CD20-positive LTB-...
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Factor IX expression stable at up to 8 years with gene therapy
SAN DIEGO – In severe hemophilia B, factor IX expression remains stable up to 8.6 years after scAAV2/8-LP1-hFIX–comediated gene therapy.
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Large cohort study IDs prognostic factors in thromboangiitis obliterans
CHICAGO – Ethnicity and limb infection are independent predictors of poor outcomes, including limb amputation, in TAO.
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ALL regimens clear disease in kids with MPAL
SAN DIEGO—Pediatric patients with mixed phenotype acute leukemia (MPAL) can achieve minimal residual disease (MRD) negativity with acute...
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Ibrutinib outperforms bendamustine and rituximab in older CLL patients
SAN DIEGO – Ibrutinib, which is now widely used in older CLL patients, provided better progression-free survival than bendamustine and rituximab...