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Lipophilic statins linked to lower mortality in ovarian cancer
Lipophilic statin use was associated with a 43% reduction in mortality.
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Novel SERD, LSZ102, shows promise for pretreated ER+ breast cancer
LSZ102 was relatively well tolerated as a single agent and in combination with ribociclib and alperisib.
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Tumor markers are ‘valuable’ for relapse detection in rare CNS tumors
Among evaluable patients, 92% of relapses were detectable by tumor markers.
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Sequential chemoradiation improves DFS in early-stage cervical cancer
The 3-year disease-free survival rate was significantly higher among patients who received sequential chemoradiation than among patients who...
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Immunotherapy combo improves ORR, PFS in PD-L1+ NSCLC
Adding tiragolumab to atezolizumab led to “clinically meaningful” improvements in patients with PD-L1–positive non–small cell lung cancer.
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No OS benefit with gefitinib vs. chemo for EGFR+ NSCLC
Adjuvant gefitinib improved disease-free survival, but not overall survival, when compared with standard chemotherapy.
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Addressing racism, bias in the American maternal mortality crisis
“I think the most important thing you can do is really consider a patient a partner in the care you give them.”
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Poziotinib provides ‘modest but meaningful’ efficacy in NSCLC subgroup
About 15% of patients achieved a response with poziotinib and 65% had a decrease in tumor size.
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ALTERNATE trial: No fulvestrant benefit in locally advanced ER+ HER2– breast cancer
The endocrine-sensitive disease rate was similar whether patients received anastrozole alone, fulvestrant alone, or fulvestrant plus anastrozole...
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LOTUS: Ipatasertib plus paclitaxel may prolong OS in TNBC
Ipatasertib provided a “clinically meaningful,” but not statistically significant, 9-month improvement in median overall survival.
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Novel penclomedine shows promise for some AYAs with CNS cancers
Two patients who responded to the treatment were in their 59th month of survival at last follow-up.
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Universal CAR-T therapy produces CRs in relapsed/refractory T-ALL
All five patients studied achieved a complete response, though one patient had a morphological relapse.
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MRD surveillance can detect relapse before imaging in early-stage NSCLC
Relapse occurred in 9 of 10 patients who were positive for minimal residual disease but had no evidence of relapse on imaging.
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The American maternal mortality crisis: The role of racism and bias
Not only do health care providers need to face their implicit biases, the health care system needs to change.