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Sarah Safranek, MLIS

Article

Woman holding iPhone

Do electronic reminder systems help patients with T2DM to lose weight?

Author:
William Kwan, MD
Jon O. Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: PROBABLY NOT—but they may augment self-management. Four-component telehealth systems—including electronic reminders,...

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Article

Peanut butter

Does early introduction of peanuts to an infant’s diet reduce the risk for peanut allergy?

Author:
Greg Jungwirth, MD
Kevin Stock, PharmD
Jon O. Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Probably not, unless the child has severe eczema or egg allergy. In a general pediatric population, introducing peanuts...

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Article

Prilosec

Does concurrent use of clopidogrel and PPIs increase CV risk in patients with ACS?

Author:
Sandy Shehata, PharmD
Jason Baker, MD
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: No. Adding a proton pump inhibitor (PPI) in patients taking antiplatelet medications such as clopidogrel for acute coronary...

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Article

Bronchiole in a patient with asthma

Does vitamin D supplementation reduce asthma exacerbations?

Author:
Jaspreet Jaura, MD
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Yes, to some extent it does, and primarily in patients with low vitamin D levels. Supplementation reduces asthma...

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Article

Child getting prophylactic antipyretic

Do prophylactic antipyretics reduce vaccination-associated symptoms in children?

Author:
Hang Chau-Glendinning, DO
Blair Baber, PharmD
Jon O. Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Yes for acetaminophen, not so much for ibuprofen. Prophylactic acetaminophen reduces the odds of febrile reactions in the...

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Article

Melanoma

Does screening by primary care providers effectively detect melanoma and other skin cancers?

Author:
Jenna Madeja, DO
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Possibly. No trials have directly assessed detection of melanoma and other skin cancers by primary care providers.

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Article

Group of people sitting and talking in a circle

Do group visits improve HbA1c more than individual visits in patients with T2DM?

Author:
Amanda Berbert, MD
Jon Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Yes. In patients with type 2 diabetes mellitus (T2DM), group visits led by health professionals or teams improved...

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Article

Boy vaping

Does using e-cigarettes increase cigarette smoking in adolescents?

Author:
Tim Asher, MD
Jenna Leah Belden, PharmD
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Probably. Electronic cigarette (e-cigarette) use by adolescents is associated with a 2- to 4-fold increase in cigarette...

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Article

Pregnant woman holding her head on a couch

How safe and effective is ondansetron for nausea and vomiting in pregnancy?

Author:
Kimberly L. Collins, MD
Megan Wilson, MD
E. Chris Vincent, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Oral ondansetron is more effective than a combination of pyridoxine and doxylamine for outpatient treatment of nausea and...

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Opinion

Is intra-articular platelet-rich plasma injection an effective treatment for knee OA?

Is intra-articular platelet-rich plasma injection an effective treatment for knee OA?

Author:
Carrie Lynn Wilcox, MD
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Probably not, based on the balance of evidence. While low-quality evidence may suggest potential benefit,...

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Article

Does amniotomy shorten spontaneous labor or improve outcomes?

Does amniotomy shorten spontaneous labor or improve outcomes?

Author:
Megan Worthley, MD
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: No. Amniotomy neither shortens spontaneous labor nor improves any of the following outcomes: length of first stage of labor...

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Article

What medical therapies work for gastroparesis?

What medical therapies work for gastroparesis?

Author:
Orion Wells, MD
Ashley Warcola, PharmD
John Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: It’s unclear if there are any highly effective medications for gastroparesis (TABLE1-10). Metoclopramide...

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Article

What’s the best VTE treatment for patients with cancer?

What’s the best VTE treatment for patients with cancer?

Author:
Thuy Pham, DO
Hannah Sundquist, PharmD
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: No head-to-head studies directly compare all the main treatments for venous thromboembolism (VTE) in cancer patients. Long-...

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Article

How effectively do ACE inhibitors and ARBs prevent migraines?

How effectively do ACE inhibitors and ARBs prevent migraines?

Author:
Brendan Morris, MD
John Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: The angiotensin-converting enzyme (ACE) inhibitor lisinopril reduces the number of migraines by about 1.5 per month in...

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Article

Do statins alter the risk or progression of dementia?

Do statins alter the risk or progression of dementia?

Author:
Tess Lang, MD
Joseph Clifton, PharmD
Jon Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED SUMMARY: No. Moderate-intensity statin therapy (with pravastatin or simvastatin) doesn’t prevent progression to dementia in...

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