Article
Does early introduction of peanuts to an infant’s diet reduce the risk for peanut allergy?
EVIDENCE-BASED ANSWER: Probably not, unless the child has severe eczema or egg allergy. In a general pediatric population, introducing peanuts...
Article
Does concurrent use of clopidogrel and PPIs increase CV risk in patients with ACS?
EVIDENCE-BASED ANSWER: No. Adding a proton pump inhibitor (PPI) in patients taking antiplatelet medications such as clopidogrel for acute coronary...
Article
Does vitamin D supplementation reduce asthma exacerbations?
EVIDENCE-BASED ANSWER: Yes, to some extent it does, and primarily in patients with low vitamin D levels. Supplementation reduces asthma...
Article
Do prophylactic antipyretics reduce vaccination-associated symptoms in children?
EVIDENCE-BASED ANSWER: Yes for acetaminophen, not so much for ibuprofen. Prophylactic acetaminophen reduces the odds of febrile reactions in the...
Article
Does screening by primary care providers effectively detect melanoma and other skin cancers?
EVIDENCE-BASED ANSWER: Possibly. No trials have directly assessed detection of melanoma and other skin cancers by primary care providers.
Article
Do group visits improve HbA1c more than individual visits in patients with T2DM?
EVIDENCE-BASED ANSWER: Yes. In patients with type 2 diabetes mellitus (T2DM), group visits led by health professionals or teams improved...
Article
Does using e-cigarettes increase cigarette smoking in adolescents?
EVIDENCE-BASED ANSWER: Probably. Electronic cigarette (e-cigarette) use by adolescents is associated with a 2- to 4-fold increase in cigarette...
Article
How safe and effective is ondansetron for nausea and vomiting in pregnancy?
EVIDENCE-BASED ANSWER: Oral ondansetron is more effective than a combination of pyridoxine and doxylamine for outpatient treatment of nausea and...
Opinion
Is intra-articular platelet-rich plasma injection an effective treatment for knee OA?
EVIDENCE-BASED ANSWER: Probably not, based on the balance of evidence. While low-quality evidence may suggest potential benefit,...
Article
Does amniotomy shorten spontaneous labor or improve outcomes?
EVIDENCE-BASED ANSWER: No. Amniotomy neither shortens spontaneous labor nor improves any of the following outcomes: length of first stage of labor...
Article
What medical therapies work for gastroparesis?
EVIDENCE-BASED ANSWER: It’s unclear if there are any highly effective medications for gastroparesis (TABLE1-10). Metoclopramide...
Article
What’s the best VTE treatment for patients with cancer?
EVIDENCE-BASED ANSWER: No head-to-head studies directly compare all the main treatments for venous thromboembolism (VTE) in cancer patients. Long-...
Article
How effectively do ACE inhibitors and ARBs prevent migraines?
EVIDENCE-BASED ANSWER: The angiotensin-converting enzyme (ACE) inhibitor lisinopril reduces the number of migraines by about 1.5 per month in...
Article
Do statins alter the risk or progression of dementia?
EVIDENCE-BASED SUMMARY: No. Moderate-intensity statin therapy (with pravastatin or simvastatin) doesn’t prevent progression to dementia in...
Article
What’s the best secondary treatment for patients who fail initial triple therapy for H pylori?
EVIDENCE-BASED ANSWER: Treating patients with Helicobacter pylori infection who have failed clarithromycin-based triple therapy with either...