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Sarah Safranek, MLIS

Article

Boy vaping

Does using e-cigarettes increase cigarette smoking in adolescents?

Author:
Tim Asher, MD
Jenna Leah Belden, PharmD
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Probably. Electronic cigarette (e-cigarette) use by adolescents is associated with a 2- to 4-fold increase in cigarette...

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Article

Pregnant woman holding her head on a couch

How safe and effective is ondansetron for nausea and vomiting in pregnancy?

Author:
Kimberly L. Collins, MD
Megan Wilson, MD
E. Chris Vincent, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Oral ondansetron is more effective than a combination of pyridoxine and doxylamine for outpatient treatment of nausea and...

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Opinion

Is intra-articular platelet-rich plasma injection an effective treatment for knee OA?

Is intra-articular platelet-rich plasma injection an effective treatment for knee OA?

Author:
Carrie Lynn Wilcox, MD
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Probably not, based on the balance of evidence. While low-quality evidence may suggest potential benefit,...

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Article

Does amniotomy shorten spontaneous labor or improve outcomes?

Does amniotomy shorten spontaneous labor or improve outcomes?

Author:
Megan Worthley, MD
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: No. Amniotomy neither shortens spontaneous labor nor improves any of the following outcomes: length of first stage of labor...

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Article

What medical therapies work for gastroparesis?

What medical therapies work for gastroparesis?

Author:
Orion Wells, MD
Ashley Warcola, PharmD
John Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: It’s unclear if there are any highly effective medications for gastroparesis (TABLE1-10). Metoclopramide...

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Article

What’s the best VTE treatment for patients with cancer?

What’s the best VTE treatment for patients with cancer?

Author:
Thuy Pham, DO
Hannah Sundquist, PharmD
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: No head-to-head studies directly compare all the main treatments for venous thromboembolism (VTE) in cancer patients. Long-...

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Article

How effectively do ACE inhibitors and ARBs prevent migraines?

How effectively do ACE inhibitors and ARBs prevent migraines?

Author:
Brendan Morris, MD
John Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: The angiotensin-converting enzyme (ACE) inhibitor lisinopril reduces the number of migraines by about 1.5 per month in...

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Article

Do statins alter the risk or progression of dementia?

Do statins alter the risk or progression of dementia?

Author:
Tess Lang, MD
Joseph Clifton, PharmD
Jon Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED SUMMARY: No. Moderate-intensity statin therapy (with pravastatin or simvastatin) doesn’t prevent progression to dementia in...

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Article

What's the best secondary treatment for patients who fail initial triple therapy for H pylori?

What’s the best secondary treatment for patients who fail initial triple therapy for H pylori?

Author:
Leanne Jones, MD
Julien Ta, PharmD
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Treating patients with Helicobacter pylori infection who have failed clarithromycin-based triple therapy with either...

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Article

How effective and safe is fecal microbial transplant in preventing C difficile recurrence?

How effective and safe is fecal microbial transplant in preventing C difficile recurrence?

Author:
Shawn Meyers, MD
Jessica Shih, PharmD
Jon O. Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Fecal microbial transplant (FMT) is reasonably safe and effective. In patients who have had multiple Clostridium difficile...

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Article

How well do POLST forms assure that patients get the end-of-life care they requested?

Author:
Jordan Collier, DO
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Quite well, for cardiopulmonary resuscitation (CPR). Most patients (91%-100%) who select “do not resuscitate” (DNR) on...

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Article

Which interventions are effective in managing parental vaccine refusal?

Author:
Dan Brelsford, MD
Elise Knutzen, PharmD
Jon O. Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: It’s unclear whether educational initiatives alone alter vaccine refusal. Although about a third of parents cite herd...

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Article

What effects—if any—does marijuana use during pregnancy have on the fetus or child?

Author:
Angela Zhang, DO
Robert Marshall, MD, MPH, MISM
Gary Kelsberg, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: The effects are unclear. Marijuana use during pregnancy is associated with clinically unimportant lower...

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Article

Do pedometers increase activity and improve health outcomes?

Author:
Devin Schock, MD
Jon O. Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Yes. In overweight and obese patients, exercise interventions using a pedometer increase steps by about a mile per day over...

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Article

Does breastfeeding affect the risk of childhood obesity?

Author:
Lindsay Gunnell, MD
Jon Neher, MD
Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Yes. Ever having breastfed during the first year of life is associated with a 15% lower risk of overweight or obesity over...

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