Leslie Mackler, MSLS

Article

Do complementary agents lower HbA1c when used with standard type 2 diabetes therapy?

Author:: Leslie Mackler, MSLS

Publish date: June 1, 2014

EVIDENCE-BASED ANSWER: No, there is no high-quality evidence that supports using complementary or alternative agents to lower hemoglobin A1c (HbA1c...

Article

When you suspect ACS, which serologic marker is best?

Author:: Leslie Mackler, MSLS

Publish date: February 1, 2014

EVIDENCE-BASED ANSWER: Measurement of troponin levels provides the most sensitive and accurate serologic information in evaluating a patient with a...

News

When You Suspect ACS, Which Serologic Marker Is Best?

Author:: Leslie Mackler, MSLS

Publish date: February 1, 2014

Article

Do oral contraceptives carry a significant risk of stroke for women with migraines?

Author:: Leslie Mackler, MSLS

Publish date: October 29, 2013

EVIDENCE-BASED ANSWER: Perhaps. Estrogen-containing oral contraceptives may raise the risk of ischemic stroke in women with migraine, particularly ...

Article

Elevated troponin but no CVD: What’s the prognosis?

Author:: Leslie Mackler, MSLS

Publish date: September 24, 2013

EVIDENCE-BASED ANSWER: Patients with elevated troponin levels and chronic renal disease, pulmonary hypertension, pulmonary embolism, chronic obstru...

Article

How should you treat a child with flat feet?

Author:: Leslie Mackler, MSLS

Publish date: June 1, 2010

EVIDENCE-BASED ANSWER: THAT DEPENDS on whether the pes planus (flatfoot) is flexible or rigid. Flexible flatfoot (FFF)—an arch that is flat o...

Article

What’s the best test for renal artery stenosis in patients with refractory hypertension?

Author:: Leslie Mackler, MSLS

Publish date: April 1, 2009

EVIDENCE-BASED ANSWER: Magnetic resonance angiography (MRA) and computed tomography angiography (CTA) are the most consistently accurate, noninvasi...

Article

Does bed rest for preeclampsia improve neonatal outcomes?

Author:: Leslie Mackler, MSLS

Publish date: November 1, 2007

EVIDENCE-BASED ANSWER: No. strict bed rest in the hospital for pregnant women with preeclampsia does not appear to lower rates of perinatal mortali...

Article

Who should receive vertebroplasty?

Author:: Leslie Mackler, MSLS

Publish date: July 1, 2006

EVIDENCE-BASED ANSWER: Percutaneous vertebroplasty has been used to treat aggressive vertebral hemangiomas, osteoporotic vertebral compression frac...

Article

What physical exam techniques are useful to detect malingering?

Author:: Leslie Mackler, MSLS

Publish date: August 1, 2005

EVIDENCE-BASED ANSWER: No examination technique objectively proves malingering (strength of recommendation [SOR]: C, expert opinion). Waddell’s sig...

Article

Can we prevent splenic rupture for patients with infectious mononucleosis?

Author:: Leslie Mackler, MSLS

Publish date: June 1, 2005

EVIDENCE- BASED ANSWER: All patients with infectious mononucleosis should be considered at risk for splenic rupture since clinical severity, labora...

Article

How should a DEXA scan be used to evaluate bisphosphonate therapy for osteoporosis?

Author:: Leslie Mackler, MSLS

Publish date: January 1, 2005

EVIDENCE-BASED ANSWER: If bone density is evaluated after initiating bisphosphonate drug therapy, it should be tested no earlier than 2 years (stre...

Article

What is the addiction risk associated with tramadol?

Author:: Leslie Mackler, MSLS

Publish date: January 1, 2005

EVIDENCE-BASED ANSWER: Tramadol (Ultram, generic and with acetaminophen in Ultracet) carries a risk of substance abuse (strength of recommendation ...

Article

Does quinine reduce leg cramps for young athletes?

Author:: Leslie Mackler, MSLS

Publish date: January 1, 2005

EVIDENCE-BASED ANSWER: Very little evidence exists regarding the use of quinine for cramps in young adult athletes. Quinine may be an effective tre...

Article

What is the best treatment for Osgood-Schlatter disease?

Author:: Leslie Mackler, MSLS

Publish date: February 1, 2004

EVIDENCE-BASED ANSWER: Osgood-Schlatter disease is a common cause of pain and tenderness at the tibial tuberosity in active adolescents. It is typi...