Cedars-Sinai

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SIRS Criteria Could Identify More Patients with Severe Sepsis

Author:: Cedars-Sinai

Publish date: June 8, 2015

Clinical question: Does inclusion of two or more SIRS criteria in the definition of severe sepsis accurately identify patients with higher mortality r...

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Trimethoprim-Sulfamethoxazole Use in Older Patients Taking Spironolactone

Author:: Cedars-Sinai

Publish date: June 8, 2015

Clinical question: Does trimethoprim-sulfamethoxazole (TMP-SMX) increase the risk of sudden death in older patients taking spironolactone? Backgrou...

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Medicare Nonpayment for Hospital-Acquired Conditions May Have Reduced Infection Rates

Author:: Cedars-Sinai

Publish date: June 8, 2015

Clinical question: What was the effect of the Centers for Medicare and Medicaid Services’ (CMS) nonpayment for hospital-acquired conditions? Backgr...

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Peri-Operative Phlebotomy Might Cause Significant Blood Loss in Cardiac Surgery Patients

Author:: Cedars-Sinai

Publish date: June 8, 2015

Clinical question: What are the frequency of laboratory testing, the average total blood volume drawn per patient, and the resulting transfusion utili...

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Clostridium Difficile Infection Rates in the U.S. in 2011

Author:: Cedars-Sinai

Publish date: June 8, 2015

Clinical question: What are the incidence, recurrence rate, and mortality rate of Clostridium difficile infection (CDI) in the U.S.

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CT Angiography Effect on Outcome for Patients with Symptomatic Chest Pain

Author:: Cedars-Sinai

Publish date: June 8, 2015

Clinical question: Does CT angiography (CTA) improve clinical outcomes in patients with new-onset stable chest pain more than functional testing? B...

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Early Goal-Directed Therapy for Sepsis Offers No Benefit Over Usual Care

Author:: Cedars-Sinai

Publish date: June 8, 2015

Background: Recent trials (ARISE, ProCESS) showed EGDT provided no mortality benefit over usual care. Questions remain about the effectiveness of inte...

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NSAID Use by Patients on Antithrombotic Therapy Has Bleeding, Cardiovascular Risks

Author:: Cedars-Sinai

Publish date: June 8, 2015

Clinical question: Is there increased risk of bleeding or cardiovascular events when using NSAIDs while on antithrombotic therapy for secondary cardio...

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Treatment of Patients with Atrial Fibrillation, Low CHA2DS2-VASc Scores

Author:: Cedars-Sinai

Publish date: June 8, 2015

Clinical question: Is anticoagulation beneficial for patients with atrial fibrillation (Afib) and low CHA2DS2-VASc score (0 for men, 1 for women) or f...

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Research Review: Ticagrelor for Post-Myocardial Infarction

Author:: Cedars-Sinai

Publish date: June 8, 2015

Clinical question: Is ticagrelor for secondary prevention indicated for more than one year after myocardial infarction (MI)? Background: The effica...

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Antibiotic Regimens Compared for Treating Uncomplicated Skin Infections

Author:: Cedars-Sinai

Publish date: May 19, 2015

Clinical question: What are the efficacy and safety of clindamycin and trimethoprim-sulfamethoxazole (TMP-SMX) for treatment of uncomplicate...