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Crohn’s disease tied to anal canal high-risk HPV infection
High-risk HPV DNA was detected in anal tissue specimens from 30% of patients with Crohn’s disease versus 18% of patients without Crohn’s disease...
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H. pylori antibiotic resistance reaches ‘alarming levels’
Resistance to clarithromycin, metronidazole, and levofloxacin reached 15% or more in almost all World Health Organization regions.
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Thiopurines linked to zoster in IBD patients
The adjusted hazard ratio for developing zoster was 1.47 (95% CI, 1.31-1.65; P less than .001) for thiopurine monotherapy, compared with...
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Budesonide topped placebo for treating lymphocytic colitis
Fully 79% of patients achieved clinical remission with budesonide.
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Norfloxacin might benefit patients with advanced cirrhosis and low ascites fluid protein levels
The mortality benefit appeared to be limited to patients with ascites fluid protein levels under 15 g/L.
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Maintaining virologic response predicted long-term survival in HBV patients with decompensated cirrhosis
An HBV DNA load less than 20 IU/mL in patients with decompensated cirrhosis significantly improved the chances of long-term survival.
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MELD sodium score tied to better transplant outcomes
Factoring hyponatremic status into liver graft allocations led to significant reductions in wait-list mortality.
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Proximal adenoma location does not predict high-grade dysplasia
The odds of high-grade dysplasia were slightly lower for proximal versus distal adenomas.
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ALEX: Alectinib showed superior CNS efficacy in ALK+ NSCLC
Time to CNS progression was significantly longer with alectinib versus crizotinib.
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Guideline: Early screening warranted if family history of nonhereditary colorectal cancer
Initial screening colonoscopy should occur at age 40-50 years, or 10 years before the age of the earliest-diagnosed first-degree relative.
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Admission eosinopenia predicted severe CDI outcomes
Significant predictors of mortality included having more comorbidities and lower systolic blood pressure at admission.
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JACOB: Dual HER2 blockade falls short in metastatic gastric cancer
In contrast to patients with breast cancer, dual HER2 blockade did not significantly improve overall survival in patients with metastatic gastric...
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Cirrhosis study finds no link between screening, liver cancer mortality
Among patients with cirrhosis, screening for hepatocellular carcinoma was not associated with reductions in liver cancer mortality.
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Proinflammatory diet linked to colorectal cancer testing positive for Fusobacterium nucleatum
Dietary scores in the highest tertile correlated with significantly increased risk (P = .03).
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Commentary: Composite risk, not age, is key for timing first colorectal cancer screening
Age may not be the colorectal cancer screening issue.