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Lusutrombopag found safe, effective for severe thrombocytopenia in patients with hepatocellular carcinoma
Lusutrombopag met the primary efficacy endpoint and did not significantly increase the rate of postprocedural thromboses, compared with placebo....
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AGA Clinical Practice Update: Diagnosis and treatment of small intestinal bacterial overgrowth
For now, a SIBO diagnosis simply means that a patient’s presenting symptoms or laboratory findings are attributed to bacterial changes in the...
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Bariatric surgery achieved long-term resolution of NASH without worsening fibrosis
In all, 84% of patients evaluated at 5 years met this primary endpoint.
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AGA Clinical Practice Update: Young adult–onset colorectal cancer diagnosis and management
In addition to receiving cancer staging or being referred to an oncologist, newly diagnosed patients should be counseled about both germline...
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Scoring system identified patients with suspected small-bowel bleeding
At a cutoff threshold of less than or equal to 0, the negative predictive value of the scoring system was 83.6%, but its positive predictive value...
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Anti-CD8a, anti-IL-17A antibodies improved immune disruption in mice with history of NASH
Treatment with anti-CD8a antibodies decreased cytotoxic T cells in all tissues tested, while antibodies targeting IL-17A reduced hepatic...
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Complete endoscopic healing tied to better Crohn’s disease outcomes
Rates of treatment failure were 25% in patients with complete endoscopic mucosal healing, compared with 48% in patients with partial mucosal...
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Studies eyes risks for poor outcomes in primary sclerosing cholangitis
Significant risk factors included younger age at diagnosis, Afro-Caribbean heritage, and male sex.
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Model identified heavy drinkers at highest risk of ALD progression
Women and men with steatohepatitis had the highest 5-year risk for liver complications.
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Switching to low-inflammatory diet linked to lower risk for Crohn’s disease
In a large observational study, switching from a high-inflammatory diet to a lower-inflammatory diet was associated with a significant decrease in...
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AAP releases new policy statement on barrier protection for teens
The policy statement has been expanded to cover multiple types of sexual activity and methods of barrier protection.
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Characterization of norovirus immunity in nonsecretor adults might provide vaccine model for children
Immunity lasted for at least 30 days for T cells, monocytes, and dendritic cells and at least 180 days for blocking antibodies.
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Real-time, computer-aided detection system significantly improved adenoma detection
The adenoma detection rate was 55% in the intervention group and 40% in the control group.
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High-def chromoendoscopy better for detecting dysplasias in patients with IBD
Detection rates were 11% for high-definition chromoendoscopy and 5% for high-definition white-light endoscopy (P = .032).
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Biopsies of ascending, descending colon alone detected microscopic colitis
The approach was 100% sensitive for diagnosing microscopic colitis.