Key clinical point: In adults with type 2 diabetes (T2D), higher albuminuria and worsening chronic kidney disease (CKD) were independently associated with a higher risk for incident stroke.
Major finding: Compared with a urine albumin-to-creatinine ratio of <30 mg/g and no CKD, moderate (adjusted hazard ratio [aHR] 1.61; P = .010) and severe (aHR 2.29; P = .001) albuminuria and worsening CKD stages (stage 1: aHR 1.76; P = .020; stage 2: aHR 1.77; P = .012; and stage 3: aHR 2.03; P = .003) were significantly associated with a higher risk for stroke, respectively.
Study details: This study included 9170 adults with T2D from the ACCORD study , of which 156 experienced stroke events over a median follow-up of 4.9 years.
Disclosures: The study did not declare any source of funding. Dr. G Fonarow reported consulting for various sources.
Source: Kaze AD et al. Diabetic kidney disease and risk of incident stroke among adults with type 2 diabetes. BMC Med. 2022;20:127 (Mar 29). Doi: 10.1186/s12916-022-02317-0