Clinical Edge

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Preop IV dexamethasone conveys relief after total knee surgery

Key clinical point: IV dexamethasone was significantly associated with pain relief in knee surgery patients at 12, 15, 18, and 21 hours post-surgery.

Major finding: Patients given IV dexamethasone averaged 11 points lower VAS scores for pain at rest and 15 points lower for pain in motion compared with placebo patients.

Study details: The data come from a randomized trial of 100 patients who underwent total knee arthroplasty.

Disclosures: The researchers had no relevant financial conflicts


Tammachote N et al. J Arthroplasty. 2019. doi: j.arth.2019.09.002