Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Scandinavian Studies Shed Light on OA Inheritance

Key clinical point: Osteoarthritis appears to be inherited mother to daughter, with paternal OA posing no increased risk to sons or daughters.

Major finding: The daughter of a mother with hand, hip, or knee OA has a 13%-44% greater risk of developing OA than if her mother didn’t have OA.

Study details: This was an analysis of the 630-patient MUST study and the Nor-Twin OA Study of 7,184 twins, as well as the offspring of all participants.

Disclosures: The presenter reported having no financial conflicts regarding the study, conducted free of commercial support.


Magnusson K et al. Osteoarthritis Cartilage. 2019 Apr;27[suppl 1]:S47, Abstract 33.