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Differential monocytic HLA-DR expression prognostically useful in PICU

Key clinical point: Researchers have identified laboratory markers potentially useful in guiding need for immunostimulatory therapy in critically ill children.

Major finding: The 6 patients who died had only a 33% rate of HLA-DR–expressing classical monocytes on day 3 after pediatric ICU admission, compared with a 63% rate in survivors of their critical illness.

Study details: This was a prospective observational study of 37 critically ill children and 37 healthy controls.

Disclosures: The presenter reported having no financial conflicts regarding the study, which was supported by the European Union and Erasmus University.


Boeddha NP et al. Pediatr Infect Dis J. 2018 Oct;37(10):1034-40.