Clinical Edge

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Underwater endoscopic mucosal resection may be an option colorectal lesions

Key clinical point: For intermediate-size colorectal lesions, underwater endoscopic mucosal resection may offer cleaner margins than does conventional EMR without increasing adverse events or procedure time.

Major finding: Underwater endoscopic mucosal resection was associated with an R0 resection rate of 69%, compared with 50% for conventional EMR (P = .011).

Study details: A prospective, randomized trial involving 211 patients with 214 colorectal lesions at multiple centers in Japan.

Disclosures: The investigators reported no external funding or conflicts of interest.


Yamashina T et al. Gastroenterology. 2019 Apr 11. doi: 10.1053/j.gastro.2019.04.005.