Key clinical point: For intermediate-size colorectal lesions, underwater endoscopic mucosal resection may offer cleaner margins than does conventional EMR without increasing adverse events or procedure time.
Major finding: Underwater endoscopic mucosal resection was associated with an R0 resection rate of 69%, compared with 50% for conventional EMR (P = .011).
Study details: A prospective, randomized trial involving 211 patients with 214 colorectal lesions at multiple centers in Japan.
Disclosures: The investigators reported no external funding or conflicts of interest.
Yamashina T et al. Gastroenterology. 2019 Apr 11. doi: 10.1053/j.gastro.2019.04.005.