Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Week's Must Reads

Intensity modulated radiation therapy may be preferable in children with extremity nonrhabdomyosarcoma soft-tissue sarcomas, Source: Rao A et al. Intl J Rad Oncology*Biology*Physics; Jan. 2019, 38-44. https://doi.org/10.1016/j.ijrobp.2018.09.005

Expanded genetic analyses of myxofibrosarcomas may guide precision therapies, Ogura K et al. Nature Communications; 17 July 2018. https://doi.org/10.1038/s41467-018-03891-9

Malignant tenosynovial giant cell tumors appear to originate from synoviocytes, Al-Ibraheemi A et al. Modern Pathology; 11 Sept. 2018. https://doi.org/10.1038/s41379-018-0129-0

Type and rate of clonal evolution vary widely in sarcoma pathogenetic subgroups, Hofvander J et al. Nature Communications 10 Sept. 2018. https://doi.org/10.1038/s41467-018-06098-0

GIST

Liquid biopsy aids assessment in advanced imatinib-resistant GIST, George S et al. ASCO 2018. Abstract 11511.

Rapid therapy changes fall short for metastatic GIST, Serrano-Garcia C et al. ASCO 2018, Abstract 11510.

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Angiosarcoma

Postop therapy for primary cardiac sarcoma, Wu Y et al. Journal of Thoracic and Cardiovascular Surgery, December 2018: 2194-2203. https://doi.org/10.1016/j.jtcvs.2018.04.127

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Chondrosarcoma

Mesenchymal progenitor cells may trigger c-Fos induced chondrogenic tumors, Abarrategi A et al. Scientific Reports; 23 Oct. 2018 https://doi.org/10.1038/s41598-018-33689-0

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Rhabdomyosarcoma

Increasing pannexin 1 levels might be a novel treatment for rhabdomyosarcoma , Xiang X et al. Oncogenesis; 21 Nov. 2018. https://doi.org/10.1038/s41389-018-0100-4

Read more in Rhabdomyosarcoma

Rare Sarcomas

MMP-14 may play a role in synvovial sarcomas, Liu M et al. Human Pathology 2018; 80:201-209. https://doi.org/10.1016/j.humpath.2017.12.031

Surgery plus post-op chemo for pulmonary artery sarcoma, Yin K et al. Journal of Thoracic and Cardiovascular Surgery 2018; 155: 1109-1115.e1 https://doi.org/10.1016/j.jtcvs.2017.10.101

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Leiomyosarcoma

Survival not improved by adjuvant chemo in uterine-confined leiomyosarcoma, Hensley M et al. Journal of Clinical Oncology, Nov.2018; https://doi.org/10.1200/JCO.18.00454

Susceptibility-weighted MR sequences aid diagnosis of uterine sarcoma, Takeuchi M et al. Clinical Imaging 2019; 53:143-150. https://doi.org/10.1016/j.clinimag.2018.10.015

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Osteosarcoma

REGOBONE: Regorafenib shows efficacy in metastatic osteosarcoma, Duffaud F et al. ASCO 2018 (annual meeting of the American Society of Clinical Oncology), Abstract 11505.

Read more in Osteosarcoma

Liposarcoma

Type and rate of clonal evolution vary widely in sarcoma pathogenetic subgroups, Hofvander J et al. Nature Communications 10 Sept. 2018. https://doi.org/10.1038/s41467-018-06098-0

Trabectedin and olaparib show promise in soft-tissue sarcomas, Grignani G et al. The Lancet Oncology 2018; 1360-1371. https://doi.org/10.1016/S1470-2045(18)30438-8

Read more in Liposarcoma