Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Week's Must Reads

Intensity modulated radiation therapy may be preferable in children with extremity nonrhabdomyosarcoma soft-tissue sarcomas, Source: Rao A et al. Intl J Rad Oncology*Biology*Physics; Jan. 2019, 38-44.

Expanded genetic analyses of myxofibrosarcomas may guide precision therapies, Ogura K et al. Nature Communications; 17 July 2018.

Malignant tenosynovial giant cell tumors appear to originate from synoviocytes, Al-Ibraheemi A et al. Modern Pathology; 11 Sept. 2018.


Type and rate of clonal evolution vary widely in sarcoma pathogenetic subgroups, Hofvander J et al. Nature Communications 10 Sept. 2018.

Trabectedin and olaparib show promise in soft-tissue sarcomas, Grignani G et al. The Lancet Oncology 2018; 1360-1371.

Read more in Liposarcoma


Liquid biopsy aids assessment in advanced imatinib-resistant GIST, George S et al. ASCO 2018. Abstract 11511.

Rapid therapy changes fall short for metastatic GIST, Serrano-Garcia C et al. ASCO 2018, Abstract 11510.

Read more in GIST

Ewing's Sarcoma

Similar outcomes for extraskeletal and skeletal Ewing sarcomas in adults, Lynch A et al. Surgical Oncology 2018: 27; 373-379.

Lurbinectedin active against Ewing’s sarcoma, Subbiah V et al. ASCO 2018, Abstract 11519.

Read more in Ewing's Sarcoma


Postop therapy for primary cardiac sarcoma, Wu Y et al. Journal of Thoracic and Cardiovascular Surgery, December 2018: 2194-2203.

Read more in Angiosarcoma


Mesenchymal progenitor cells may trigger c-Fos induced chondrogenic tumors, Abarrategi A et al. Scientific Reports; 23 Oct. 2018

Read more in Chondrosarcoma


Increasing pannexin 1 levels might be a novel treatment for rhabdomyosarcoma , Xiang X et al. Oncogenesis; 21 Nov. 2018.

Read more in Rhabdomyosarcoma

Rare Sarcomas

MMP-14 may play a role in synvovial sarcomas, Liu M et al. Human Pathology 2018; 80:201-209.

Surgery plus post-op chemo for pulmonary artery sarcoma, Yin K et al. Journal of Thoracic and Cardiovascular Surgery 2018; 155: 1109-1115.e1

Read more in Rare Sarcomas


Survival not improved by adjuvant chemo in uterine-confined leiomyosarcoma, Hensley M et al. Journal of Clinical Oncology, Nov.2018;

Susceptibility-weighted MR sequences aid diagnosis of uterine sarcoma, Takeuchi M et al. Clinical Imaging 2019; 53:143-150.

Read more in Leiomyosarcoma


REGOBONE: Regorafenib shows efficacy in metastatic osteosarcoma, Duffaud F et al. ASCO 2018 (annual meeting of the American Society of Clinical Oncology), Abstract 11505.

Read more in Osteosarcoma