Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Week's Must Reads

Intensity modulated radiation therapy may be preferable in children with extremity nonrhabdomyosarcoma soft-tissue sarcomas, Source: Rao A et al. Intl J Rad Oncology*Biology*Physics; Jan. 2019, 38-44. https://doi.org/10.1016/j.ijrobp.2018.09.005

Expanded genetic analyses of myxofibrosarcomas may guide precision therapies, Ogura K et al. Nature Communications; 17 July 2018. https://doi.org/10.1038/s41467-018-03891-9

Malignant tenosynovial giant cell tumors appear to originate from synoviocytes, Al-Ibraheemi A et al. Modern Pathology; 11 Sept. 2018. https://doi.org/10.1038/s41379-018-0129-0

Liposarcoma

Type and rate of clonal evolution vary widely in sarcoma pathogenetic subgroups, Hofvander J et al. Nature Communications 10 Sept. 2018. https://doi.org/10.1038/s41467-018-06098-0

Trabectedin and olaparib show promise in soft-tissue sarcomas, Grignani G et al. The Lancet Oncology 2018; 1360-1371. https://doi.org/10.1016/S1470-2045(18)30438-8

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GIST

Liquid biopsy aids assessment in advanced imatinib-resistant GIST, George S et al. ASCO 2018. Abstract 11511.

Rapid therapy changes fall short for metastatic GIST, Serrano-Garcia C et al. ASCO 2018, Abstract 11510.

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Ewing's Sarcoma

Similar outcomes for extraskeletal and skeletal Ewing sarcomas in adults, Lynch A et al. Surgical Oncology 2018: 27; 373-379. https://doi.org/10.1016/j.suronc.2018.05.016

Lurbinectedin active against Ewing’s sarcoma, Subbiah V et al. ASCO 2018, Abstract 11519.

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Angiosarcoma

Postop therapy for primary cardiac sarcoma, Wu Y et al. Journal of Thoracic and Cardiovascular Surgery, December 2018: 2194-2203. https://doi.org/10.1016/j.jtcvs.2018.04.127

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Chondrosarcoma

Mesenchymal progenitor cells may trigger c-Fos induced chondrogenic tumors, Abarrategi A et al. Scientific Reports; 23 Oct. 2018 https://doi.org/10.1038/s41598-018-33689-0

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Rhabdomyosarcoma

Increasing pannexin 1 levels might be a novel treatment for rhabdomyosarcoma , Xiang X et al. Oncogenesis; 21 Nov. 2018. https://doi.org/10.1038/s41389-018-0100-4

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Rare Sarcomas

MMP-14 may play a role in synvovial sarcomas, Liu M et al. Human Pathology 2018; 80:201-209. https://doi.org/10.1016/j.humpath.2017.12.031

Surgery plus post-op chemo for pulmonary artery sarcoma, Yin K et al. Journal of Thoracic and Cardiovascular Surgery 2018; 155: 1109-1115.e1 https://doi.org/10.1016/j.jtcvs.2017.10.101

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Leiomyosarcoma

Survival not improved by adjuvant chemo in uterine-confined leiomyosarcoma, Hensley M et al. Journal of Clinical Oncology, Nov.2018; https://doi.org/10.1200/JCO.18.00454

Susceptibility-weighted MR sequences aid diagnosis of uterine sarcoma, Takeuchi M et al. Clinical Imaging 2019; 53:143-150. https://doi.org/10.1016/j.clinimag.2018.10.015

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Osteosarcoma

REGOBONE: Regorafenib shows efficacy in metastatic osteosarcoma, Duffaud F et al. ASCO 2018 (annual meeting of the American Society of Clinical Oncology), Abstract 11505.

Read more in Osteosarcoma