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Relationship of RA and Periodontal Health Explored

PLoS One; ePub 2018 Sep 19; Beyer, Zaura, et al

In patients with rheumatoid arthritis (RA) with active disease, anti-inflammatory medication as part of RA therapy was associated with better oral health status and a healthier subgingival microbiome compared to that of RA patients in remission, especially those in remission who were current smokers. This according to a recent study undertaken to describe the bacterial component of the subgingival microbiome in RA patients and to relate this to RA disease activity and periodontal status. Patients with chronic established RA (n=78) were periodontally examined and their subgingival plaque samples were collected; their clinical and laboratory data on RA status and medication were obtained from medical records. Bacterial DNA was quantified by universal 16S rDNA qPCR, and Porphyromonas gingivalis by species-specific qPCR. They found:

  • Active RA was diagnosed in 58% of the patients and periodontitis in 82% (mild: 9%, moderate: 55%, severe: 18%).
  • P. gingivalis was present in 14% of the samples.
  • Different levels of gingival bleeding, periodontal probing depth, RA disease status, prednisolone use, and smoking were associated with significantly different microbiome compositions.

Citation:

Beyer K, Zaura E, Brandt BW, et al. Subgingival microbiome of rheumatoid arthritis patients in relation to their disease status and periodontal health. [Published online ahead of print September 19, 2018]. PLoS One. doi:10.1371/journal.pone.0202278.

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