Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

MBDA Score Independently Predictive of Relapsing RA

PLoS One; ePub 2018 May 23; Moghadam, et al

For patients with rheumatoid arthritis (RA) with stable low disease activity (LDA) who stopped TNF inhibitor (TNFi) treatment, a high baseline multi-biomarker disease activity (MBDA) score was independently predictive of disease relapse within 12 months. This according to a study that analyzed 439 RA patients post hoc who were randomized to stop TNFi treatment in the POET study. 3 indicators of disease relapse were assessed over 12 months: 1) restarting TNFi treatment, 2) escalation of any disease-modifying antirheumatic drug (DMARD) therapy and 3) physician-reported flare. MBDA score was assessed at baseline. Researchers found:

  • At baseline, 50.1%, 35.3%, and 14.6% of patients had low (<30), moderate (30−44), or high (>44) MBDA scores, respectively.
  • Within 12 months, 49.9% of patients had restarted TNFi medication, 59.0% had escalation of any DMARD, and 57.2% had ≥1 physician-reported flare.
  • MBDA score was associated with each indicator of relapse.
  • At least 1 indicator of relapse was observed in 59.5%, 68.4%, and 81.3% of patients with low, moderate or high MBDA scores, respectively.


Moghadam MG, Lamers-Karnebeek FBG, Vonkeman HE, et al. Multi-biomarker disease activity score as a predictor of disease relapse in patients with rheumatoid arthritis stopping TNF inhibitor treatment. [Published online ahead of print May 23, 2018]. PLoS One. doi:10.1371/journal.pone.0192425.

This Week's Must Reads

NSAIDs Linked with Increased Stress Fracture Risk, J Bone Miner Res; ePub 2018 Oct 23; Hughes, et al

Knee Pain and Physical Activity Preference Examined, Osteoarthritis Cartilage; ePub 2018 Oct 15; Pinto, et al

Age at Menarche Linked to Osteoporosis Etiology, Bone; 2018 Dec; Zhang, Greenbaum, Zhang, et al

Link Found Between Viral Pathogens and Arthritis, Int J Rheumatol; 2018 Oct 1; Shmagel, et al

Diabetics Show Accelerated Knee Joint Degeneration, Skeletal Radiol; ePub 2018 Oct 24; Neumann, et al

Must Reads in Rheumatoid Arthritis

MBDA Score, RA Disease Activity Measures Linked , Arthritis Care Res; ePub 2018 Oct 15; Johnson, et al

Patient-Reported Outcome Measures Assessed, Clin Rheumatol; ePub 2018 Sep 12; Renskers, et al

RA and the Mucosal Origins Hypothesis Examined, Nat Rev Rheumatol; 2018 Sep; Holers, et al

RA Linked to Increased Risk of Sexual Dysfunction, J Rheumatol; 2018 Oct; Zhao, Li, Wang, et al

Heath-Related QOL Compared in RA, PsA, and Controls, Ann Rheum Dis; 2018 Sep; Michelsen, Uhlig, et al