Lower bone mineral density (BMD) levels are independently associated with the severity of coronary artery calcium (CAC) that predicts mortality, according to a recent study that investigated the relation of BMD levels with CAC and mortality in both genders across ethnicities. Researchers assessed 5,590 consecutive at-risk subjects without known coronary artery disease (CAD) (age 57 ± 12, 69% male), who underwent non-enhanced cardiac computed tomography, and were followed for a mean of 8 years. CAC stratified based on the severity to CAC 0, 1–100, 101–400, and 400+. Low-BMD levels were defined as levels below median (180 mg/cm3). They found:
- BMD levels were proportionally lowering with the severity of CAC in both genders, especially in postmenopausal women.
- The risk of each standard deviation reduction in BMD levels increased with the severity of CAC, as compared to CAC=0 across ethnicities.
- Low BMD levels were an independent predictor of mortality and event-free survival rate decreased from 99% in those within normal BMD levels to 93% in those with low BMD levels.
- Furthermore, a significant link between low BMD levels and CAC >0 with increased risk of mortality was noted.
Ahmadi N, Mao SS, Hajsadeghi F, et al. The relation of low levels of bone mineral density with coronary artery calcium and mortality. [Published online ahead of print April 27, 2018]. Osteoporos Int. doi:10.1007/s00198-018-4524-7.
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