Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Transcript Comparison of Meniscus, OA and non-OA

Osteoarthritis Cartilage; ePub 2017 Dec 16; Brophy, et al

Numerous transcripts with potential relevance to the pathogenesis of osteoarthritis (OA) are differentially expressed (DE) in OA and non-OA menisci, a recent study found. These data suggest an involvement of epigenetically regulated histone deacetylation in meniscus tears as well as expression of long noncoding RNAs (lncRNAs). RNA microarrays were used to identify transcripts DE in meniscus obtained from 12 OA and 12 non-OA patients. The non-OA specimens were obtained at the time of arthroscopic partial meniscectomy (APM). Real-time PCR was performed on selected transcripts. Investigators found:

  • 168 transcripts significantly DE between OA (75 elevated, 93 repressed) and non-OA samples (≥1.5-fold) were identified.
  • Among these, CSN1S1, COL10A1, WIF1, and SPARCL1 were the most prominent transcripts elevated in OA meniscus, POSTN and VEGFA were most highly repressed in OA meniscus.
  • Transcripts elevated in OA meniscus represented response to external stimuli, cell-migration and cell-localization while those repressed in OA meniscus represented histone deacetylase activity (related to epigenetics) and skeletal development.


Brophy RH, Zhang B, Cai L, Wright RW, Sandell LJ, Rai MF. Transcriptome comparison of meniscus from patients with and without osteoarthritis. [Published online ahead of print December 16, 2017]. Osteoarthritis Cartilage. doi:10.1016/j.joca.2017.12.004.

This Week's Must Reads

Pain and Catastrophizing in Patients with RA, J Clin Rheumatol; ePub 2018 Jun 22; Cohen, et al

Delay in DMARD Initiation in Newly Diagnosed RA, Semin Arthritis Rheum; ePub 2018 Jul 18; Kimsey, et al

Fatigue an Overall Problem for Patients with RA, Rheumatol Int; ePub 2018 Jul 16; Walter, et al

Biological Agent Safety in Older vs Younger Patients, Semin Arthritis Rheum; ePub 2018 Jul 31; Dalal, et al

Higher Body Fat, Obesity in Women Linked with RA, Arthritis Care Res; ePub 2018 Jul 5; Linauskas, et al

Must Reads in Osteoarthritis

Moderate Physical Activity May Ease Knee OA Pain, Osteoarthritis Cartilage; ePub 2018 Jul 23; Song, et al

Increase in Knee, Hip Arthroplasties Found in AS, J Rheumatol; ePub 2018 Jul; Ward

Joint Hypermobility May Be Linked to Ankle/Foot OA, Arthritis Care Res; ePub 2018 Jun 28; Golightly, et al

FDA Approves Consensi for Osteoarthritis Pain, FirstWord Pharma news release; 2018 May 31

Poor Sleep, Less Physical Activity Linked in KOA, Arthritis Care Res; ePub 2018 May 22; Gilbert, et al