Numerous transcripts with potential relevance to the pathogenesis of osteoarthritis (OA) are differentially expressed (DE) in OA and non-OA menisci, a recent study found. These data suggest an involvement of epigenetically regulated histone deacetylation in meniscus tears as well as expression of long noncoding RNAs (lncRNAs). RNA microarrays were used to identify transcripts DE in meniscus obtained from 12 OA and 12 non-OA patients. The non-OA specimens were obtained at the time of arthroscopic partial meniscectomy (APM). Real-time PCR was performed on selected transcripts. Investigators found:
- 168 transcripts significantly DE between OA (75 elevated, 93 repressed) and non-OA samples (≥1.5-fold) were identified.
- Among these, CSN1S1, COL10A1, WIF1, and SPARCL1 were the most prominent transcripts elevated in OA meniscus, POSTN and VEGFA were most highly repressed in OA meniscus.
- Transcripts elevated in OA meniscus represented response to external stimuli, cell-migration and cell-localization while those repressed in OA meniscus represented histone deacetylase activity (related to epigenetics) and skeletal development.
Brophy RH, Zhang B, Cai L, Wright RW, Sandell LJ, Rai MF. Transcriptome comparison of meniscus from patients with and without osteoarthritis. [Published online ahead of print December 16, 2017]. Osteoarthritis Cartilage. doi:10.1016/j.joca.2017.12.004.
This Week's Must Reads
Obesity, Weight Loss Linked with Disability in RA, Arthritis Care Res; ePub 2018 Apr 29; Baker, et al
RA Clinic Visits Lack Documented BP Communication, J Clin Rheumatol; ePub Apr 24; Bartels, Johnson, et al
Mechanisms and Clinical Effects of Bone Loss in RA, Calcif Tiss Int; 2018 May; Shim, Stavre, et al
No Link: Exposure to Passive Smoking and RA Risk, Ann Rheum Dis; ePub 2018 May 3; Hedström, et al
THR/TKR Rates, and bDMARDs in Patients with RA, Ann Rheum Dis; 2018 May; Cordtz, Hawley, et al
Must Reads in Osteoarthritis
Obesity and Late-Life Mobility Issues Post-Surgery, Arthritis Care Res; ePub 2018 Apr 25; Shadyab, et al
GJH More Common in Whites than African Americans, Arthritis Res Ther; ePub 2018 Apr 18; Flowers, et al
Diabetes, Accelerated Cartilage Degeneration Linked, Osteoarthritis Cartilage; ePub 2018 Mar 29; Neumann, et al
Pain and Functional Trajectories for Knee OA Found, Osteoarthritis Cartilage; 2018 April; Lee, Harvey, et al
Insomnia, Sleep Apnea Common in Veterans with OA, BMC Musculoskelet Disord; ePub 2018 Mar 9; Taylor, et al