Patient report of both symptoms, or at least 1 positive exam finding and at least 1 symptom, could be used to identify knees at increased risk of effusion-synovitis (ES) in knees with early stage osteoarthritis (OA), either for screening purposes in clinical evaluation, or for study sample enrichment with an inflammatory phenotype. This according to a recent study that evaluated the diagnostic performance of knee physical exam findings and participant-reported symptoms for MRI-detected ES among knees with early and late-stage OA. Through the Osteoarthritis Initiative, researchers examined 344 knees with early OA (312 participants) and 216 with late-stage OA (186 participants). They found:
- For the early OA sample, the highest sensitivity for medium/large ES was achieved with a positive finding for any of the physical exam maneuvers and/or participant-reported symptoms (81.0).
- Both knee symptoms in combination had a prevalence of 11.7% and yielded the highest estimated positive predictive value (50.0) and likelihood ratio positive (5.2).
- In late-stage OA knees, exam findings and symptoms provided minimal information beyond the prevalence.
Berlinberg A, Ashbeck EL, Roemer FW, et al. Diagnostic performance of knee physical exam and participant-reported symptoms for MRI-detected effusion-synovitis among participants with early or late stage knee osteoarthritis: Data from the Osteoarthritis Initiative. [Published online ahead of print September 20, 2018]. Osteoarthritis Cartilage. doi:10.1016/j.joca.2018.09.004.
This Week's Must Reads
Patient Global Assessment Discordance in RA vs OA, Rheumatol Int; ePub 2018 Oct 6; Castrejon, et al
Chronic Lung Disease, RA, and Impact on Survival , Clin Rheumatol; ePub 2018 Oct 2; England, et al
RA and Systemic Sclerosis Share Similar Impairments, Disabil Rehab; 2018 Oct; Poole, New, et al
Synovial Hypertrophy With/Without Doppler Activity , Arthritis Res Ther; ePub 2018 Oct 3; Tersley, et al
Cortical Interruptions in Finger Joints in RA, J Bone Miner Res; 2018 Sep; Peters, et al
Must Reads in Osteoarthritis
>50% of Arthritis Sufferers Not Being Treated, J Clin Rheumatol; ePub 2018 Sep 18; Theis, et al
Varus Thrust Linked with Worsening Knee Pain, Arthritis Care Res; ePub 2018 Sep 22; Wink, et al
Does Exercise Contribute to Radiographic Worsening?, Arthritis Care Res; ePub 2018 Sep 20; Jayabalan, et al
Significance of Patient-Reported Symptoms of Knee OA, Osteoarthritis Cartilage; ePub 2018 Sep 20; Berlinberg, et al
Incident Hand OA Linked with Reduced Telomere Length, Osteoarthritis Cartilage; ePub 2018 Aug 30; McAlindon, et al