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Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Poor Sleep, Less Physical Activity Linked in KOA

Arthritis Care Res; ePub 2018 May 22; Gilbert, et al

Poor sleep quality is associated with less physical activity in persons with or at risk for knee osteoarthritis (KOA), according to a recent studyResearchers analyzed accelerometer‐measured physical activity and clinical data from Osteoarthritis Initiative (OAI) participants. They found:

  • Of the 1,892 OAI participants with complete data, 300 (16%) reported restless sleep ≥3 days in the past week.
  • Participants reporting much (3‐4 days/week) and most (5‐7 days/week) restless sleep had 11.9% and 23.7% less weekly minutes of moderate‐vigorous activity, respectively, compared to participants reporting rare restless sleep (<1 day/week).
  • These differences persisted after accounting for age, gender, race, body mass index, medical comorbidity, KOA severity, and pain.
  • Differences related to restless sleep were largely attenuated by the presence of high depressive symptoms and low energy levels.


Gilbert AL, Lee J, Song J, et al. The relationship between self‐reported restless sleep and objectively measured physical activity in adults with knee osteoarthritis. [Published online ahead of print May 22, 2018]. Arthritis Care Res. doi:10.1002/acr.23581.

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