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Periarticular Bone Predicts Knee OA Progression

Semin Arthritis Rheum; ePub 2018 Jan 17; Lo, et al

Baseline and most rates of periarticular bone change associate with knee osteoarthritis (OA) structural progression, highlighting the close relationship between subchondral bone and joint space narrowing (JSN), a recent study found. Researchers conducted a 12- to 18-month longitudinal study using the Osteoarthritis Initiative, which included 444 participants, mean age 64.2 + 9.2 years, BMI 29.5 + 4.6 kg/m2, and 52% male at baseline. Participants received knee dual-energy x-ray absorptiometry (DXA), trabecular magnetic resonance (MR) imaging, and x-rays. Knee DXAs generated proximal tibial medial:lateral periarticular bone mineral density (paBMD) measures. Proximal tibial trabecular MR images were assessed for trabecular morphometry: apparent bone volume fraction (BVF), trabecular number, thickness, and spacing. Researchers found:

  • Medial JSN (radiographic progression) occurred in 40 participants (9%).
  • Higher baseline medial:lateral paBMD, apparent BVF, trabecular number and thickness, and lower baseline and decreased trabecular spacing were all associated with more progression of JSN in the medial compartment.
  • The rate of change in medial:lateral paBMD, apparent BVF, and spacing were associated with more medial JSN.


Lo GH, Schneider E, Driban JB, et al. Periarticular bone predicts knee osteoarthritis progression: Data from the Osteoarthritis Initiative. [Published online ahead of print January 17, 2018]. Semin Arthritis Rheum. doi:10.1016/j.semarthrit.2018.01.008.

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