Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Diabetes, Accelerated Cartilage Degeneration Linked

Osteoarthritis Cartilage; ePub 2018 Mar 29; Neumann, et al

Diabetes mellitus seems to be a risk factor for developing early osteoarthritis (OA), with an accelerated degeneration of the articular cartilage in the knee, according to a recent study. 196 diabetics from the Osteoarthritis Initiative cohort were matched in small sets for age, sex, BMI, and Kellgren-Lawrence (KL) score with 196 non-diabetic controls. Knee cartilage semi-automatic segmentation was performed on 2D multi-slice, multi-echo, spin-echo sequences. Researchers found:

  • Both study groups were similar in age (63.3 vs 63.0 years), BMI (30.9 vs 31.2 kg/m2), sex (female 53.6% vs male 54.1%), and KL score distribution.
  • In diabetics, except for the patella, all compartments showed a significantly higher increase in mean T2 values when compared to non-diabetic controls.
  • Global T2 values increased almost twice as much; 1.77ms vs 0.98ms.
  • Additionally, global T2 values showed a significantly higher increase in the bone layer, and in a separate analysis of the texture parameters, diabetics also showed consistently higher texture values, indicating a more disordered cartilage composition.

Neumann J, Hofmann FC, Heilmeier U, et al. Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: Data from the Osteoarthritis Initiative. [Published online ahead of print March 29, 2018]. Osteoarthritis Cartilage. doi:10.1016/j.joca.2018.03.010.

This Week's Must Reads

Inflammation and Estimated CV Risk in RA, Arthritis Rheumatol; 2018 Sep; Yu, Yang, et al

Women with RA, JIA at Risk for Preterm Delivery , Arthritis Care Res; ePub 2018 Aug 21; Smith, et al

Fatigue and Physical Capacity Link in RA Examined, Rheumatol Int; ePub 2018 Aug 29; Demmelmaier, et al

Rheum4U Web-Based Tool Proves Efficacious, Clin Exp Rheumatol; ePub 2018 Aug 29; Barber, et al

Depression is Risk Factor for Development of RA, RMD Open; 2018 Jul 11; Vallerand, Lewinson, et al

Must Reads in Osteoarthritis

Thresholds in Strength Function in Knee OA, Arthritis Care Res; ePub 2018 Aug 29; Bacon, et al

Knee OA and Risk of Falls Among Older Adults, Arthritis Care Res; ePub 2018 Aug 21; Barbour, et al

Bariatric Surgery in Those with Knee OA Deemed Safe, Osteoarthritis Cartilage; ePub 2018 Aug 1; Gong, et al

Pain Severity and Depression in Knee OA Examined, Osteoarthritis Cartilage; ePub 2018 Aug 6; Rathbun, et al

Moderate Physical Activity May Ease Knee OA Pain, Osteoarthritis Cartilage; ePub 2018 Jul 23; Song, et al