Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Rheumatic Disease and Lung Transplant Mortality

Rheumatology (Oxford); ePub 2018 Feb 13; Bernstein, et al

The presence of an autoimmune rheumatic disease (ARD) was not associated with increased mortality after lung transplantation in adults with pulmonary arterial hypertension (PAH), according to a recent study. Researchers conducted a retrospective cohort study of 93 adults with ARD-PAH and 222 adults with PAH who underwent lung transplantation in the US between May 4, 2005, and March 9, 2015, using data from the United Network for Organ Sharing. They examined associations between diagnosis and survival after lung transplantation using stratified Cox models adjusted for potential confounding recipient factors. They found that among adults undergoing lung transplantation in the US, there was no difference in the multivariable-adjusted mortality rate between those with ARD-PAH and those with PAH.


Bernstein EJ, Bathon HJM, Lederer DJ. Survival of adults with systemic autoimmune rheumatic diseases and pulmonary arterial hypertension after lung transplantation. [Published online ahead of print February 13, 2018]. Rheumatology (Oxford). doi:10.1093/rheumatology/kex527.

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