Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Poor Sleep Quality and Fracture Risk Examined

J Bone Miner Res; ePub 2018 Nov 21; Cauley, et al

Short and long sleep duration and poor sleep quality were independently associated with increased odds of recurrent falls, according to a recent study. In addition, short sleep was associated with modest increase in fractures. To investigate the association between self‐reported sleep and falls and fractures, researchers prospectively studied 157,306 women in the Women's Health Initiative (WHI) using information on sleep quality, sleep duration, and insomnia from questionnaires. They found:

  • In multivariable adjusted models, including adjustment for comorbidity, medications, and physical function, women who were short (≤5 hours) and long (≥10 hours) sleepers had increased odds of recurrent falls.
  • Poor sleep quality, insomnia, and more sleep disturbances were also associated with an increased odds of recurrent falls.
  • Short sleep was associated with an increased risk of all fractures, and upper limb, lower limb, and central body fractures, but not hip fractures, with hazard ratios ranging from 1.10 to 1.13.
Citation:

Cauley JA, Hovey KM, Stone KL, et al. Characteristics of self‐reported sleep and the risk of falls and fractures: The Women's Health Initiative (WHI). [Published online ahead of print November 21, 2018]. J Bone Miner Res. doi:10.1002/jbmr.3619.

This Week's Must Reads

Diabetes, Abnormal Glucose Metabolism, and RKOA, Arthritis Care Res; ePub 2018 Nov 12; Rogers-Soeder, et al

Poor Sleep Quality and Fracture Risk Examined, J Bone Miner Res; ePub 2018 Nov 21; Cauley, et al

Screening for Cognitive Dysfunction Risk in SLE, Lupus; ePub 2018 Nov 27; Chalhoub, Luggen

Depression in African American Women with SLE, Lupus; ePub 2018 Nov 27; Jordan, Thompson, et al

Impact of Prescription Drugs on Fragility Fractures, Osteoporos Int; 2018 Dec; Munson, et al

Must Reads in Mixed Topics

Diabetes, Abnormal Glucose Metabolism, and RKOA, Arthritis Care Res; ePub 2018 Nov 12; Rogers-Soeder, et al

Poor Sleep Quality and Fracture Risk Examined, J Bone Miner Res; ePub 2018 Nov 21; Cauley, et al

Screening for Cognitive Dysfunction Risk in SLE, Lupus; ePub 2018 Nov 27; Chalhoub, Luggen

Depression in African American Women with SLE, Lupus; ePub 2018 Nov 27; Jordan, Thompson, et al

Impact of Prescription Drugs on Fragility Fractures, Osteoporos Int; 2018 Dec; Munson, et al