Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Lean Mass, Muscle Strength and Power, in Older Men

J Bone Miner Res; ePub 2018 Apr 27; Chalhoub, et al

In older men, stronger associations were observed for appendicular lean mass (ALM) compared to muscle strength and power, a recent study found. Researchers studied the association between ALM, grip strength, and leg power, and central quantitative computed tomography (QCT) parameters in 2,857 men aged ≥65 years; peripheral QCT was available on a subset (n=786). ALM, grip strength, and leg power were measured by dual‐energy X‐ray absorptiometry (DXA), Jamar dynamometer, and the Nottingham Power Rig, respectively. Percent differences of bone parameters between lowest (Q1) and highest quartiles (Q4) of ALM, grip strength, and leg power were reported. They found:

  • ALM was significantly associated with central and peripheral QCT parameters: percent higher values (Q4 vs Q1) ranging from 3.3% (cortical volumetric bone mineral density [vBMD] of the femoral neck) to 31% (vertebral strength index of the spine).
  • Grip strength was only significantly associated with radial parameters: percent higher values (Q4 vs Q1) ranging from 2.5% (periosteal circumference) to 7.5% (33% axial strength index –SSIx).
  • Leg power was associated with vertebral strength and lower cross‐sectional area with percent lower values (Q4 vs Q1) of ‐11.9% and ‐2.7%, respectively.


Chalhoub D, Boudreau R, Greenspan S, et al. Associations between lean mass, muscle strength and power, and skeletal size, density and strength in older men. [Published online ahead of print April 27, 2018]. J Bone Miner Res. doi:10.1002/jbmr.3458.

This Week's Must Reads

Patient Global Assessment Discordance in RA vs OA, Rheumatol Int; ePub 2018 Oct 6; Castrejon, et al

Chronic Lung Disease, RA, and Impact on Survival , Clin Rheumatol; ePub 2018 Oct 2; England, et al

RA and Systemic Sclerosis Share Similar Impairments, Disabil Rehab; 2018 Oct; Poole, New, et al

Synovial Hypertrophy With/Without Doppler Activity , Arthritis Res Ther; ePub 2018 Oct 3; Tersley, et al

Cortical Interruptions in Finger Joints in RA, J Bone Miner Res; 2018 Sep; Peters, et al

Must Reads in Mixed Topics

Patients with SSc and Pulmonary Hypertension Risk, J Rheumatol; ePub 2018 Oct 1; Hsu, Chung, et al

Outpatient Engagement Lowers Suicide Risk in FM, Arthritis Care Res; ePub 2018 Sep 7; McKernan, et al

T2D Risk in PsA Higher than in General Population , Rheumatology (Oxford); ePub 2018 Sep 6; Charlton, et al

Statins and Systemic Autoimmune Rheumatic Disease, J Rheumatol; ePub 2018 Sep 1; Jorge, Lu, et al

Patients with Diabetes Perform Worse after TKA, Arthritis Care Res; ePub 2018 Aug 29; Cheuy, et al