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Fragility Fracture Risk Linked with Sarcoidosis

Osteoporos Int; 2018 May; Ungprasert, et al

Patients with sarcoidosis have an increased risk of fragility fracture, which is primarily driven by the higher incidence of distal forearm fracture, according to a recent study. This study was conducted using a previously identified population-based cohort of 345 patients with incident sarcoidosis from Olmsted County, Minnesota. Sex- and age-matched subjects randomly selected from the same underlying population were used as comparators. Medical records of cases and comparators were reviewed for baseline characteristics and incident fragility fracture. Researchers found:

  • Fragility fractures were observed in 34 patients with sarcoidosis, corresponding to a cumulative incidence of 5.6% at 10 years, while 18 fragility fractures were observed among comparators for a cumulative incidence of 2.4% at 10 years.
  • The hazard ratio (HR) of fragility fractures among cases compared with comparators was 2.18.
  • The risk of fragility fracture by site was significantly higher among patients with sarcoidosis and was due to a higher rate of distal forearm fracture (HR 3.58).
  • Statistically non-significant increased risk was also observed in proximal femur (HR 1.66) and proximal humerus (HR 3.27).
  • Risk of vertebral fracture was not increased (HR 1.00).


Ungprasert P, Crowson CS, Matteson EL. Risk of fragility fracture among patients with sarcoidosis: A population-based study 1976–2013—supplementary presentation. Osteoporos Int. 2018;29(5):1201. doi:10.1007/s00198-017-4074-4.

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