Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Fragility Fracture Risk Linked with Sarcoidosis

Osteoporos Int; 2018 May; Ungprasert, et al

Patients with sarcoidosis have an increased risk of fragility fracture, which is primarily driven by the higher incidence of distal forearm fracture, according to a recent study. This study was conducted using a previously identified population-based cohort of 345 patients with incident sarcoidosis from Olmsted County, Minnesota. Sex- and age-matched subjects randomly selected from the same underlying population were used as comparators. Medical records of cases and comparators were reviewed for baseline characteristics and incident fragility fracture. Researchers found:

  • Fragility fractures were observed in 34 patients with sarcoidosis, corresponding to a cumulative incidence of 5.6% at 10 years, while 18 fragility fractures were observed among comparators for a cumulative incidence of 2.4% at 10 years.
  • The hazard ratio (HR) of fragility fractures among cases compared with comparators was 2.18.
  • The risk of fragility fracture by site was significantly higher among patients with sarcoidosis and was due to a higher rate of distal forearm fracture (HR 3.58).
  • Statistically non-significant increased risk was also observed in proximal femur (HR 1.66) and proximal humerus (HR 3.27).
  • Risk of vertebral fracture was not increased (HR 1.00).


Ungprasert P, Crowson CS, Matteson EL. Risk of fragility fracture among patients with sarcoidosis: A population-based study 1976–2013—supplementary presentation. Osteoporos Int. 2018;29(5):1201. doi:10.1007/s00198-017-4074-4.

This Week's Must Reads

>50% of Arthritis Sufferers Not Being Treated, J Clin Rheumatol; ePub 2018 Sep 18; Theis, et al

Patients with SSc and Pulmonary Hypertension Risk, J Rheumatol; ePub 2018 Oct 1; Hsu, Chung, et al

Varus Thrust Linked with Worsening Knee Pain, Arthritis Care Res; ePub 2018 Sep 22; Wink, et al

Does Exercise Contribute to Radiographic Worsening?, Arthritis Care Res; ePub 2018 Sep 20; Jayabalan, et al

Significance of Patient-Reported Symptoms of Knee OA, Osteoarthritis Cartilage; ePub 2018 Sep 20; Berlinberg, et al

Must Reads in Mixed Topics

Patients with SSc and Pulmonary Hypertension Risk, J Rheumatol; ePub 2018 Oct 1; Hsu, Chung, et al

Outpatient Engagement Lowers Suicide Risk in FM, Arthritis Care Res; ePub 2018 Sep 7; McKernan, et al

T2D Risk in PsA Higher than in General Population , Rheumatology (Oxford); ePub 2018 Sep 6; Charlton, et al

Statins and Systemic Autoimmune Rheumatic Disease, J Rheumatol; ePub 2018 Sep 1; Jorge, Lu, et al

Patients with Diabetes Perform Worse after TKA, Arthritis Care Res; ePub 2018 Aug 29; Cheuy, et al