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SLE Damage Compared in 2 Cohorts of Dominicans

Lupus; ePub 2018 Aug 9; Geraldino-Pardilla, et al

Dominican patients in New York City (NYC) with systemic lupus erythematosus (SLE) had a higher Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) than those in the Dominican Republic (DR). This according to a recent study that evaluated SLE disease burden in 2 Dominican communities, Washington Heights in NYC and Santiago in the DR. Disease activity (SLE Disease Activity Index 2000 [SLEDAI-2K]) and SDI were cross-sectionally measured in 76 Dominican SLE patients from the Columbia University Lupus Cohort in NYC and compared with 75 Dominican SLE patients living in Santiago. Researchers found:

  • Disease activity was mild in both groups (SLEDAI-2K of 3 in NYC vs 4 in the DR).
  • NYC Dominicans had more discoid lesions, positive anti-dsDNA, and anti-SSB antibodies.
  • Dominicans in the DR used more corticosteroids, had less medical insurance, lower educational level, and were more likely to be unemployed, whereas more Dominicans in NYC smoked.
  • NYC patients had a higher SDI compared with SLE patients in the DR (0.96 vs 0.24).
  • Statistical significance was maintained in adjusted analysis (1.26 vs 0.57).


Geraldino-Pardilla L, Kapoor T, Canto I, et al. Damage accrual in systemic lupus erythematosus in Dominicans in New York City and the Dominican Republic. [Published online ahead of print August 9, 2018]. Lupus. doi:10.1177%2F0961203318791764.

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