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Remission, Low Disease Activity Compared in SLE

Arthritis Rheumatol; ePub 2018 May 27; Petri, et al

Lupus Low Disease Activity State (LLDAS) is an easier target to achieve than Clinical Remission On Treatment and results in reduced risk of long‐term damage, according to a recent study. However, even a small percentage of time in Clinical Remission On Treatment was associated with reduced damage. Researchers analyzed data from 1,356 systemic lupus erythematosus patients in the Hopkins Lupus Cohort, followed quarterly, with 77,105 person‐months observed from 1987 to 2016. 3 outcome measures were considered: Clinical Remission with No Treatment, Clinical Remission On Treatment, and LLDAS. They found:

  • Patients achieved LLDAS in 50% of their follow‐up while they achieved Clinical Remission with No Treatment, or Clinical Remission On Treatment in only 13% and 27% of their follow‐up visits, respectively.
  • The rates of damage consistently declined as the percentage of prior time in either LLDAS or Clinical Remission On Treatment increased.
  • Spending a short proportion of prior time in Clinical Remission On Treatment (<25% of time) was associated with a relatively low rate of damage (1.01 per 10 person‐years vs 1.82 events per 10 person-years for those never in achieving that condition).

Petri M, Magder LS. Comparison of remission and lupus low disease activity state in damage prevention in a United States systemic lupus erythematosus cohort. [Published online ahead of print May 27, 2018]. Arthritis Rheumatol. doi:10.1002/art.40571.

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