Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Lack of Sleep, Transition to SLE, May Be Linked

Lupus; ePub 2018 May 28; Young, Munroe, et al

Lack of sleep may be associated with transitioning to systemic lupus erythematosus (SLE), independent of early clinical manifestations of SLE that may influence sleep duration, a recent study found. 436 relatives of SLE patients who did not have SLE themselves at baseline were evaluated again an average of 6.3 (± 3.9) years later. 56 individuals transitioned to SLE (≥4 cumulative American College of Rheumatology [ACR] criteria). Sleep duration, medication use, and medical history were assessed by questionnaire; ACR criteria were confirmed by medical record review. Researchers found:

  • Reporting sleeping <7 hours per night at baseline was more common in those who subsequently transitioned than those who did not transition to SLE (55% vs 32%).
  • Those who transitioned to SLE were more likely to sleep <7 hours per night than those who did not transition to SLE adjusting for age, sex, and race.
  • This association remained after individual adjustment for conditions and early symptoms that could affect sleep, including prednisone use, vitamin D deficiency, and number of ACR criteria.


Young KA, Munroe ME, Harley JB, et al. Less than 7 hours of sleep per night is associated with transitioning to systemic lupus erythematosus. [Published online ahead of print May 28, 2018]. Lupus. doi:10.1177/0961203318778368.

This Week's Must Reads

NSAIDs Linked with Increased Stress Fracture Risk, J Bone Miner Res; ePub 2018 Oct 23; Hughes, et al

Knee Pain and Physical Activity Preference Examined, Osteoarthritis Cartilage; ePub 2018 Oct 15; Pinto, et al

Age at Menarche Linked to Osteoporosis Etiology, Bone; 2018 Dec; Zhang, Greenbaum, Zhang, et al

Link Found Between Viral Pathogens and Arthritis, Int J Rheumatol; 2018 Oct 1; Shmagel, et al

Diabetics Show Accelerated Knee Joint Degeneration, Skeletal Radiol; ePub 2018 Oct 24; Neumann, et al

Must Reads in Lupus & Connective Tissue Diseases

Frequent ED Utilization Among Persons with SLE, Arthritis Care Res; ePub 2018 Oct 8; Lee, Lin, et al

Child-Onset SLE, Myopericardial Incidences Linked, Lupus; ePub 2018 Oct 14; Chang, Xiao, et al

Pesticide Exposure Linked to SLE Risk in Black Women, Lupus; ePub 2018 Oct 11; Williams, Chang, et al

Patients with SSc and Pulmonary Hypertension Risk, J Rheumatol; ePub 2018 Oct 1; Hsu, Chung, et al

Improving Vaccination Rates in Patients with SLE, J Rheumatol; ePub 2018 Sep 1; Garg, Tsagaris, et al