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Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Lack of Sleep, Transition to SLE, May Be Linked

Lupus; ePub 2018 May 28; Young, Munroe, et al

Lack of sleep may be associated with transitioning to systemic lupus erythematosus (SLE), independent of early clinical manifestations of SLE that may influence sleep duration, a recent study found. 436 relatives of SLE patients who did not have SLE themselves at baseline were evaluated again an average of 6.3 (± 3.9) years later. 56 individuals transitioned to SLE (≥4 cumulative American College of Rheumatology [ACR] criteria). Sleep duration, medication use, and medical history were assessed by questionnaire; ACR criteria were confirmed by medical record review. Researchers found:

  • Reporting sleeping <7 hours per night at baseline was more common in those who subsequently transitioned than those who did not transition to SLE (55% vs 32%).
  • Those who transitioned to SLE were more likely to sleep <7 hours per night than those who did not transition to SLE adjusting for age, sex, and race.
  • This association remained after individual adjustment for conditions and early symptoms that could affect sleep, including prednisone use, vitamin D deficiency, and number of ACR criteria.


Young KA, Munroe ME, Harley JB, et al. Less than 7 hours of sleep per night is associated with transitioning to systemic lupus erythematosus. [Published online ahead of print May 28, 2018]. Lupus. doi:10.1177/0961203318778368.

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