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Decoding Raised Nitrated Nucleosomes Levels in SLE

Arthritis Res Ther; ePub 2017 Dec 22; Ferreira, et al

Serum nitrated nucleosomes (NN) levels rise at the time of a neuropsychiatric (NP) event in a proportion of patients with systemic lupus erythematosus (SLE), a recent study found, Researchers obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort. This included 216 patients with NP events and 2 matched controls with SLE but no NP events for each of these patients. For the NP patients, researchers tested samples taken before, during, and after the NP event. They found:

  • 26 patients had events attributed to SLE according to the most stringent SLICC attribution rule.
  • In these patients, there was no association between onset of event and elevated serum NN.
  • In 190 patients in whom events were not attributed to SLE by the SLICC rules, median serum NN was elevated at the onset of event.
  • The predominant clinical features in this group of 190 patients were headache, mood disorders, and anxiety.
Citation:

Ferreira I, Croca S, Raimondo MG, et al. Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study. [Published online ahead of print December 22, 2017]. Arthritis Res Ther. doi:10.1186/s13075-017-1495-6.

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