Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Decoding Raised Nitrated Nucleosomes Levels in SLE

Arthritis Res Ther; ePub 2017 Dec 22; Ferreira, et al

Serum nitrated nucleosomes (NN) levels rise at the time of a neuropsychiatric (NP) event in a proportion of patients with systemic lupus erythematosus (SLE), a recent study found, Researchers obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort. This included 216 patients with NP events and 2 matched controls with SLE but no NP events for each of these patients. For the NP patients, researchers tested samples taken before, during, and after the NP event. They found:

  • 26 patients had events attributed to SLE according to the most stringent SLICC attribution rule.
  • In these patients, there was no association between onset of event and elevated serum NN.
  • In 190 patients in whom events were not attributed to SLE by the SLICC rules, median serum NN was elevated at the onset of event.
  • The predominant clinical features in this group of 190 patients were headache, mood disorders, and anxiety.

Ferreira I, Croca S, Raimondo MG, et al. Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study. [Published online ahead of print December 22, 2017]. Arthritis Res Ther. doi:10.1186/s13075-017-1495-6.

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