Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Adverse Pregnancy Outcomes in Women with SLE

Arthritis Care Res; ePub 2017 Dec 29; Kaplowitz, et al

For African American women with systemic lupus erythematosus (SLE) without antiphospholipid antibodies (aPL), a recent study found that socioeconomic status (SES) is a key contributor to disparities in adverse pregnancy outcomes (APO), despite monthly care from experts, whereas other factors contribute to disparities in SLE with aPL. Data were from the PROMISSE (Predictors of Pregnancy Outcome: Biomarkers in Antiphospholipid Antibody Syndrome and Systemic Lupus Erythematosus) study, a multicenter study that enrolled 346 patients with SLE and 62 patients with SLE and aPL (50% white, 20% African American, 17% Hispanic, 12% Asian/Pacific Islander). Measures of SES were educational attainment, median community income, and community education. Researchers found:

  • The frequency of APO in white women with SLE, with and without aPL, was 29% and 11%, respectively.
  • For African American and Hispanic women, it was approximately 2-fold greater.
  • In African American women with SLE alone, adjustment for clinical variables attenuated the odds ratio (OR) from 2.7 to 2.3, and after additional adjustment for SES, there were no longer significant differences in APO compared to whites.

Kaplowitz ET, Ferguson S, Guerra M, et al. Contribution of socioeconomic status to racial/ethnic disparities in adverse pregnancy outcomes among women with systemic lupus erythematosus. [Published online ahead of print December 29, 2017]. Arthritis Care Res. doi:10.1002/acr.23263.

This Week's Must Reads

Obesity, Weight Loss Linked with Disability in RA, Arthritis Care Res; ePub 2018 Apr 29; Baker, et al

RA Clinic Visits Lack Documented BP Communication, J Clin Rheumatol; ePub Apr 24; Bartels, Johnson, et al

Mechanisms and Clinical Effects of Bone Loss in RA, Calcif Tiss Int; 2018 May; Shim, Stavre, et al

No Link: Exposure to Passive Smoking and RA Risk, Ann Rheum Dis; ePub 2018 May 3; Hedström, et al

THR/TKR Rates, and bDMARDs in Patients with RA, Ann Rheum Dis; 2018 May; Cordtz, Hawley, et al

Must Reads in Lupus & Connective Tissue Diseases

Determining Hospitalization Risk Factors for Lupus, Lupus; ePub 2018 Apr 18; Li, Madhoun, et al

Causes, Predictors of Hospital Readmission in SLE, J Rheumatol; ePub 2018 Apr 15; Nangit, et al

Blacks with SLE Have Increased Comorbidity Burden, Arthritis Res Ther; ePub 2018 Apr 10; Barnado, et al

Dedicated Lupus Clinics Offer Better Care Quality, Arthritis Care Res; ePub 2018 Apr 2; Arora, et al

SLE Diagnostic Contrasts in American Native Group, Lupus; ePub 2018 Mar 19; McDougall, et al