Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Does Exercise Contribute to Radiographic Worsening?

Arthritis Care Res; ePub 2018 Sep 20; Jayabalan, et al

In persons with or at higher risk for knee osteoarthritis (OA), age, sex, body mass index (BMI), and pain – but not objectively measured average daily minutes of sedentary or moderate‐vigorous activity – were associated with subsequent worsening of Kellgren-Lawrence (KL) grade, a recent study found. In Osteoarthritis Initiative participants with or at higher risk for knee OA enrolled in an accelerometer sub-study at 48m (study baseline), physical activity was measured by uniaxial accelerometer (ActiGraph GT1M). Radiographic progression was defined as any 48m‐96m KL grade worsening. Researchers found:

  • 1,206 persons [mean age 64 years (SD 9), 631 (52%) women, BMI 28 (5), average daily sedentary activity 602 minutes (86), light activity 284 minutes (75), moderate‐vigorous activity 20 minutes (20)] contributed 1,978 knees; 267 (14%) had KL worsening.
  • In the multivariable model, age, sex, BMI, and pain, but neither sedentary activity (adjusted OR 0.99) nor moderate‐vigorous activity (adjusted OR 1.00) were associated with KL worsening.


Jayabalan P, Kocherginsky M, Chang A, et al. Physical activity and worsening of radiographic findings in persons with or at higher risk of knee osteoarthritis. [Published online ahead of print September 20, 2018]. Arthritis Care Res. doi:10.1002/acr.23756.

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