Eli Lilly and Company has announced that the US Food and Drug Administration (FDA) has approved Taltz (ixekizumab) injection 80 mg/mL for the treatment of adults with active psoriatic arthritis (PsA). Taltz was first approved by the FDA in March 2016 for the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
Indications: Taltz is a humanized interleukin-17A antagonist indicated for the treatment of adults with active PsA.
Dosage/administration: For PsA, the recommended dose is 160 mg by subcutaneous injection (2 80 mg injections) at week 0, followed by 80 mg every 4 weeks. For PsA patients with coexistent moderate-to-severe plaque psoriasis, refer to the dosing regimen for plaque psoriasis. Taltz may be administered alone or in combination with a conventional disease-modifying antirheumatic drug (DMARD).
Adverse reactions: Most common (≥1%) adverse reactions associated with Taltz treatment are injection site reactions, upper respiratory tract infections, nausea, and tinea infections.
Lilly’s Taltz (ixekizumab) receives US FDA approval for the treatment of active psoriatic arthritis. [news release]. Indianapolis, IN: Eli Lilly and Company. December 2, 2017. www.firstwordpharma.com/node/1526704. Accessed December 4, 2017.
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