In a 20-year follow-up matched case-cohort study, all-cause and cardiovascular disease (CVD) mortality were significantly increased in patients with rheumatoid arthritis (RA) from 1994-2003, but not in patients diagnosed after 2004. Patients with disease onset 1994-2008 and 10 matched comparators for each case were linked to the Norwegian Cause of Death Registry. Hazard ratios for all-cause and CVD mortality were calculated for 5, 10, 15, and 20 years of observation using stratified Cox regression models. Researchers found:
- Patients diagnosed with RA from 1994-2003 had significantly increased mortality vs controls.
- Mortality was not significantly increased in patients diagnosed with RA from 2004 - 2008.
- The risk of mortality for those diagnosed with RA before 2004 was increased throughout the observation period.
Provan SA, et al. Trends in all-cause and cardiovascular mortality in patients with incident rheumatoid arthritis: a 20-year follow-up matched case-cohort study. [Published online ahead of print August 29, 2019]. Rheumatology. doi: 10.1093/rheumatology/kez371.