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Telomere Shortening, Elevated Oxidant Stress in RA

Clin Rheumatol; 2018 Dec; Gamal, Hammam, et al

Rheumatoid arthritis (RA) is a disease in which markers of telomere shortening and elevated oxidant stress correlate with disease activity, a recent study found. Researchers enrolled 61 RA patients and 15 healthy controls. Demographic data, clinical examination, and disease activity status were evaluated in the patients with RA. Serum levels of chitinase and NAG (telomere markers) were determined by biochemical reactions using colloidal chitin and NAG as substrates, respectively. Nitric oxide and superoxide dismutase (oxidative stress markers) were determined colometrically and spectrophotometrically, respectively, in both the sera of patients with RA and controls. Results were correlated with disease activity. They found:

  • Indices of telomere shortening and oxidative markers were significantly higher in RA patients compared to controls.
  • These indices were correlated with signs of disease activity, including number of swollen and tender joints, Disease Activity Score-28, and inflammatory markers.

Gamal RM, Hammam N, Zakary MM, et al. Telomere dysfunction-related serological markers and oxidative stress markers in rheumatoid arthritis patients: Correlation with diseases activity. Clin Rheumatol. 2018;37(12):3239-3246. doi:10.1007/s10067-018-4318-5.