Clinical Edge

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Steroids linked to increased hypertension in RA

Key clinical point: Glucocorticoid doses higher than 7.5 mg/day were significantly associated with hypertension; cumulative dosage was not tied to any clear pattern of risk.

Major finding: In Cox proportional hazards modeling, glucocorticoid use was associated with a 17% increased risk for hypertension (hazard ratio, 1.17; 95% confidence interval, 1.10-1.24).

Study details: A retrospective cohort study of 17,760 patients who were newly diagnosed with RA between 1992 and 2019 and were included in the Clinical Practice Research Datalink

Disclosures: The study was supported by the Centre for Epidemiology Versus Arthritis and by the National Institute for Health Research Manchester Biomedical Research Centre. One author has received consultancy fees from Google and Bayer unrelated to this study.


Costello RE et al. Rheumatology. 2020 June 27. doi: 10.1093/rheumatology/keaa209.