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Remission and Low Disease Activity in Patients With RA

In patients with rheumatoid arthritis (RA), attaining remission is highly specific for attaining low disability and normal health-related quality of life (HRQoL), a new study found. Researchers studied 571 patients in 2 clinical trials, and 1,693 patients in a 10-year routine care cohort. They assessed the frequency and sustainability of remission and low-disease activity (LDA)/remission, variability in DAS28-ESR after remission, sensitivity/specificity of remission, and LDA/remission at identifying patients with low disability levels and normal HRQoL. Among the findings:

  • Point remission and remission/LDA were common but were rarely sustained.
  • Following attaining remission, DAS28-ESR levels varied substantially.
  • Most patients attaining point remission were in remission at study end-points.
  • Attaining a DAS28-ESR ≤3.2 had a better balance of specificity and sensitivity for attaining positive outcomes.

Citation:

Scott IC, et al. The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life. Semin Arthritis Rheum. 2019;49(1):20-26. doi: 10.1016/j.semarthrit.2018.12.006.