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RA Disease Activity & Risk of RA-ILD

Active rheumatoid arthritis (RA) is associated with increased risk for developing RA-interstitial lung disease (RA-ILD), a new study found. Researchers investigated disease activity and RA-ILD risk using the Brigham RA Sequential Study. All participants had RA according to accepted criteria. Disease activity scoring using 28 joints and covariate data were measured prospectively at annual study visits. Among the details:

  • Among 1,419 study participants (mean age 55.8 years), 68.6% were seropositive.
  • 85 incident RA-ILD cases were identified during mean 8.9 years of follow-up/subject.
  • Moderate/high disease activity had multivariable hazard ration of 2.22 for RA-ILD compared to remission/low.
  • Risk for RA-ILD increase across disease activity categories; 2.08 for moderate and 3.48 for high.
  • For every unit increase in DAS28, RA-ILD risk increased by 35%.


Sparks JA, He X, Huang J, et al. Rheumatoid arthritis disease activity predicting incident clinically-apparent RA-associated interstitial lung disease. [Published online ahead of print April 5, 2019]. Arthritis Rheumatol. doi:10.1002/art.40904.