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RA and SLE Linked to Adverse Outcomes After Acute CV Events

Both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are consistently associated with adverse outcomes following acute cardiovascular (CV) events, a new study found. The population-based study identified adult patients who experienced first-time acute myocardial infarction (n = 191,008), intracranial hemorrhage (n = 169,923) and ischemic stroke (n = 486,890) over a 13-year period. Odds ratios of in-hospital mortality and hazard ratios of overall mortality and adverse outcomes during long-term follow-up in relation to RA and SLE were estimated. Among the findings:

  • In each cohort, 748, 410, and 1,419 patients had established RA; 256, 292, and 622 patients had SLE.
  • Among acute myocardial infarction patients, RA and SLE were associated with in-hospital morality and overall mortality.
  • RA and SLE increased the risk of major adverse cardiac events.
  • After intracranial hemorrhage, patients with RA and SLE had higher risks of in-hospital mortality and overall mortality.
  • After ischemic stroke, RA and SLE increased in-hospital mortality.


Lai CH, et al. Outcomes of acute cardiovascular events in rheumatoid arthritis and systemic lupus erythematosus: a population-based study. [Published online ahead of print October 10, 2019]. Rheumatology. doi:10.1093/rheumatology/kez456.