Neutrophils undergo marked activation and cell death in rheumatoid arthritis (RA), with neutrophil biomarkers providing added clinical value in monitoring and prognosis of RA patients, a new study found. Markers of neutrophil activation (calprotectin) and cell death (NET) were analyzed in plasma from 3 cross-sectional RA cohorts and healthy individuals using ELISA. A longitudinal inception cohort (n=247), seen for follow-up a median of 8 years later was used for predictive analysis. Researchers found:
- Markers of neutrophil activation and cell death were increased in patients with RA vs healthy controls.
- Calprotectin levels correlated with CDAI and distinguished between patients in remission and active disease.
- Levels of NETs were associated with heightened levels of cell-free citrulline and inflammation.
Bach M, et al. A neutrophil activation biomarker panel in prognosis and monitoring of patients with rheumatoid arthritis. [Published online ahead of print July 28, 2019]. Arthritis Rheumatol. doi:10.1002/art.41062.