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Lifetime Risk of Knee and Hip Replacement in RA

The lifetime risk of knee and hip replacement for individuals with a diagnosis of rheumatoid arthritis (RA) is approximately double that of the general population, a recent study found. Diagnosis of RA was identified using primary care records, with knee and hip replacement observed in linked hospital records. Researchers found:

  • There were 13,961 individuals with a diagnosis of RA included in the study.
  • Lifetime risk of knee replacement and hip replacement was estimated to be 22% and 17%, respectively, following a diagnosis of RA for the average patient profile.
  • Risks were higher for younger patients.


Burn E, Edwards CJ, Murray DW, et al. Lifetime risk of knee and hip replacement following a diagnosis of RA: Findings from a cohort of 13,961 patients from England. [Published online ahead of print April 22, 2019]. Rheumatology. doi: 10.1093/rheumatology/kez143.