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Heath-Related QOL Compared in RA, PsA, and Controls

Ann Rheum Dis; 2018 Sep; Michelsen, Uhlig, et al

Health-related quality of life was overall similar in patients with rheumatoid arthritis (RA) and patients with psoriatic arthritis (PsA)—with a tendency to worse scores in PsA—and worse compared with general population controls, according to a recent study. Analyses of covariance were performed to compare Short-Form 36 (SF-36) measures between first-time enrolled patients with RA (n=3,898) and PsA (n=1,515) in a prospective, observational, multicenter, disease modifying anti-rheumatic drug (DMARD) study (6-month follow-up) and general population controls (n=2,323). Researchers found:

  • In age and gender-adjusted analyses, patients with PsA compared with patients with RA had similar Physical Component Summary (PCS), Mental Component Summary (MCS), and Short-Form 6 dimensions (SF-6D), worse vitality and general health, but better physical functioning at 0/6 months.
  • With additional 28-joint disease activity scores adjustment as a proxy for joint inflammation, PCS, most scale scores, and SF-6D were worse in patients with PsA than patients with RA at 0/3/6 months.
  • PCS was more impaired than MCS both in RA and PsA compared with general population controls.


Michelsen B, Uhlig T, Sexton J, et al. Health-related quality of life in patients with psoriatic and rheumatoid arthritis: Data from the prospective multicentre NOR-DMARD study compared with Norwegian general population controls. Ann Rheum Dis. 2018;77(9):1290-1294.