Clinical Edge

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Genetics and epigenetics could predict response to RA therapies

Key clinical point: Gene expression and DNA methylation patterns show association with treatment response in rheumatoid arthritis.

Major finding: A machine learning model based on gene expression and epigenetic features shows accuracy in predicting RA treatment response.

Study details: An observational cohort study involving 80 patients with rheumatoid arthritis.

Disclosures: The study was supported by AbbVie, and two authors were supported by the China Scholarship Council and the Netherlands Organisation for Scientific Research. No conflicts of interest were declared.


Tao W et al. Arthritis Rheumatol. 2020 Sep 10. doi: 10.1002/art.41516.