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Exercise Linked with Protective CV Risk in RA

J Clin Rheumatol; 2018 ePub May 25; Byram, et al

More self-reported exercise in patients with rheumatoid arthritis (RA) was associated with a protective cardiovascular (CV) risk factor profile, including lower waist-hip ratio, higher HDL particle concentration, lower vascular stiffness, and a lower prevalence of hypertension, according to a recent, cross-sectional study. Patient-reported exercise outside of daily activities was quantified by time and metabolic equivalents per week (METmin/week) and CV risk factors including blood pressure, standard lipid profiles, lipoprotein particle concentrations (NMR spectroscopy), and vascular indices were measured in 165 patients with RA. Researchers found:

  • Over half (54%) of RA patients did not exercise.
  • Among those who did exercise, median value for exercise duration was 113 min/week, and exercise metabolic equivalent expenditure was 484 METmin/week.
  • Disease activity (measured by DAS28 score), C-reactive protein, waist-hip ratio, and prevalence of hypertension were lower in patients who exercised compared to those who did not but standard lipid profile and body mass index were not significantly different.
  • Patients who exercised had significantly higher concentrations of HDL particles and lower vascular stiffness as measured by pulse wave velocity.
Citation:

Byram K, Oeser A, MacRae L, Fazio S, Stein MC, Ormseth MJ. Exercise is associated with increased small HDL particle concentration and decreased vascular stiffness in rheumatoid arthritis. [Published online ahead of print May 25, 2018]. J Clin Rheumatol. doi:10.1097/RHU.0000000000000809.

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